β-肾上腺素受体阻滞剂与钙拮抗剂联合治疗
Combination therapy with beta-adrenoceptor blockers and calcium antagonists.
作者信息
Dargie H J
出版信息
Br J Clin Pharmacol. 1986;21 Suppl 2(Suppl 2):155S-160S. doi: 10.1111/j.1365-2125.1986.tb02865.x.
Abstract
Verapamil and nifedipine enhance the hypotensive and anti-anginal effects of beta-adrenoceptor blocking drugs. The combination of beta-adrenoceptor blocking drugs with nifedipine may pose fewer safety problems than the combination with verapamil especially in ischaemic heart disease when left ventricular function is suspect. Verapamil as a single agent may be as effective as a beta-adrenoceptor blocking drug in angina and provide a suitable alternative. Careful supervision is required when verapamil is combined with beta-adrenoceptor blockers for both angina and hypertension but reported clinical problems in hypertension are few.
摘要
维拉帕米和硝苯地平可增强β-肾上腺素受体阻断药的降压及抗心绞痛作用。β-肾上腺素受体阻断药与硝苯地平联用可能比与维拉帕米联用带来的安全性问题更少，尤其在怀疑左心室功能的缺血性心脏病中。维拉帕米作为单一药物在心绞痛治疗中可能与β-肾上腺素受体阻断药同样有效，并提供了合适的替代选择。维拉帕米与β-肾上腺素受体阻断药联用于治疗心绞痛和高血压时需要仔细监测，但报道的高血压临床问题较少。
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本文引用的文献
1
Calcium antagonists.钙拮抗剂
Eur Heart J. 1980 Jun;1(3):225-37. doi: 10.1093/oxfordjournals.eurheartj.a061123.
2
Clinical efficacy of verapamil alone and combined with propranolol in treating patients with chronic stable angina pectoris.维拉帕米单用及联合普萘洛尔治疗慢性稳定型心绞痛患者的临床疗效。
Am J Cardiol. 1981 Jul;48(1):131-9. doi: 10.1016/0002-9149(81)90582-8.
3
Nifedipine and left ventricular function in beta-blocked patients.硝苯地平与β受体阻滞剂治疗患者的左心室功能
Br Heart J. 1981 Apr;45(4):457-9. doi: 10.1136/hrt.45.4.457.
4
Hemodynamic and electrophysiologic effects of verapamil and nifedipine in patients on propranolol.
Am J Cardiol. 1982 Oct;50(4):704-710. doi: 10.1016/0002-9149(82)91222-x.
5
Combined therapy with verapamil and propranolol in chronic stable angina.维拉帕米与普萘洛尔联合治疗慢性稳定型心绞痛。
Am J Cardiol. 1982 Jan;49(1):125-32. doi: 10.1016/0002-9149(82)90286-7.
6
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9
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