Li Yu-xi, Li Jun-hong, Zhou Da-wang
Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Yi Chuan. 2017 Jul 20;39(7):607-616. doi: 10.16288/j.yczz.17-064.
Liver cancer and diseases have become the leading cause of deaths in China. Liver diseases including liver failure and liver cancer can be genetic or caused by a variety of factors that damage the liver, such as viruses and alcohol overdose. However, the underlying mechanisms that maintain liver homeostasis remain unclear. Recent studies show that the Hippo signaling pathway plays a critical role in maintaining liver tissue homeostasis. Dysregulation of the Hippo signaling pathway impairs liver regeneration and remarkly enhances liver overgrowth and tumorigenesis. In this review, we summarize recent progresses on the roles and regulation mechanisms of the Hippo signaling pathway in liver development and diseases.
肝癌及肝病已成为中国的主要死因。包括肝衰竭和肝癌在内的肝病可能是遗传性的，也可能由多种损害肝脏的因素引起，如病毒和过量饮酒。然而，维持肝脏内稳态的潜在机制仍不清楚。最近的研究表明，Hippo信号通路在维持肝组织内稳态中起关键作用。Hippo信号通路失调会损害肝脏再生，并显著促进肝脏过度生长和肿瘤发生。在本综述中，我们总结了Hippo信号通路在肝脏发育和疾病中的作用及调控机制的最新进展。
