Pilchova Ivana, Klacanova Katarina, Tatarkova Zuzana, Kaplan Peter, Racay Peter
Biomedical Center Martin JFM CU and Department of Medical Biochemistry JFM CU, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Martin, Slovakia.
Oxid Med Cell Longev. 2017;2017:6797460. doi: 10.1155/2017/6797460. Epub 2017 Jul 5.
Mg is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage-dependent Ca channels and K channels and on Ca-binding proteins. In general, Mg is considered as the main intracellular antagonist of Ca, which is an essential secondary messenger initiating or regulating a great number of cellular functions. This review examines the effects of Mg on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca handling, and apoptosis.
镁是一种对细胞生理和功能具有多效性影响的必需矿物质。它作为几种重要酶的辅助因子，作为离子通道（如电压依赖性钙通道和钾通道）以及钙结合蛋白的调节剂。一般来说，镁被认为是钙的主要细胞内拮抗剂，钙是启动或调节大量细胞功能的必需第二信使。本综述探讨了镁对线粒体功能的影响，特别关注能量代谢、线粒体钙处理和细胞凋亡。
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