镍催化嘌呤碱基与卤代烃的C-H活化反应。
Nickel-catalyzed C-H activation of purine bases with alkyl halides.
作者信息
Ruan Zhixiong, Ghorai Debasish, Zanoni Giuseppe, Ackermann Lutz
机构信息
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstraße 2, 37077 Goettingen, Germany.
出版信息
Chem Commun (Camb). 2017 Aug 10;53(65):9113-9116. doi: 10.1039/c7cc05011a.
PMID:28759075
Abstract
C-H alkylations of purine nucleosides were achieved by means of user-friendly nickel catalysis with ample substrate scope and high levels of chemo, site and regio control, which among others enabled the direct fluorescent labeling of purines in terms of late stage diversification.
摘要
嘌呤核苷的C-H烷基化反应通过用户友好的镍催化实现，具有广泛的底物范围以及高度的化学、位点和区域选择性控制，这尤其使得嘌呤能够在后期多样化过程中进行直接荧光标记。
Zotero 插件