阻塞性睡眠呼吸暂停患者持续气道正压通气治疗前后的认知功能和抑郁状态
Cognitive function and depressivity before and after cpap treatment in obstructive sleep apnea patients.
作者信息
Hobzova Milada, Hubackova Lia, Vanek Jakub, Genzor Samuel, Ociskova Marie, Grambal Ales, Prasko Jan
机构信息
Department of Respiratory Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
Department of Clinical Psychology, University Hospital Olomouc, and Faculty of Medicine and Dentistry, Czech Republic.
出版信息
Neuro Endocrinol Lett. 2017 Jul;38(3):145-153.
OBJECTIVE
The target of the investigation was to find if there is any improvement of depressive symptoms and cognitive functioning after continuous positive airway pressure (CPAP) treatment in the severe obstructive apnea (OSA) patients.
METHOD
The study included 59 patients treated with CPAP for OSA in the Sleep Laboratory of the Department of Respiratory Medicine. Thirty-eight patients were treated with CPAP for one month, and twenty-one patients were in a control group. We used the following methods: Test of Visual Memory (ViMe), Numeric Rectangle, d2 (test of attention), and the Beck Depression Inventory-II, respectively.
RESULTS
Among the OSA patients, there were statistically significant improvements in all parameters: attention, working memory, and depressive symptoms after the treatment with CPAP. We found a statistically significant positive connection between the decrease in depressive symptoms and the improvement in attention. In the control group, there were no improvements in the investigated factors.
CONCLUSIONS
According to our results, the patients with sleep apnoea improved their mood and cognitive functions during the treatment by the CPAP device.
目的
本研究的目标是探寻重度阻塞性睡眠呼吸暂停（OSA）患者在持续气道正压通气（CPAP）治疗后抑郁症状和认知功能是否有改善。
方法
该研究纳入了呼吸内科睡眠实验室中59例接受CPAP治疗的OSA患者。38例患者接受了为期一个月的CPAP治疗，21例患者作为对照组。我们分别采用了以下方法：视觉记忆测试（ViMe）、数字矩形测试、d2注意力测试以及贝克抑郁量表第二版。
结果
在OSA患者中，经CPAP治疗后，所有参数（注意力、工作记忆和抑郁症状）均有统计学意义上的显著改善。我们发现抑郁症状的减轻与注意力的改善之间存在统计学意义上的显著正相关。在对照组中，所研究的因素没有改善。
结论
根据我们的研究结果，睡眠呼吸暂停患者在使用CPAP设备治疗期间情绪和认知功能得到了改善。
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