Department of Pathology, University of Otago, Christchurch, New Zealand.
Department of Anesthesia, University of Otago, Christchurch, New Zealand.
J Infect. 2017 Oct;75(4):293-300. doi: 10.1016/j.jinf.2017.07.005. Epub 2017 Jul 29.
To determine alterations of circulating levels of hydrogen sulfide and substance P in patients with sepsis compared to non-sepsis patients with similar disease severity and organ dysfunction.
This study included 23 septic and 14 non-septic patients during 2015-16 study period at the Christchurch Hospital Intensive Care Unit, Christchurch, New Zealand. Blood samples were collected from the time of admission to 96 h, with collection at different time points (0 h, 12 h, 24 h, 48 h, 72 h and 96 h) and subjected to measurement of hydrogen sulfide, substance P, procalcitonin, C-reactive protein, interleukin-6 and lactate levels.
Patients with sepsis showed higher circulating hydrogen sulfide and substance P levels compared to patients without sepsis. Hydrogen sulfide levels were significantly higher at 12 h (1.45 vs 0.75 μM; p < 0.05) and 24 h (1.11 vs 0.72 μM; p < 0.01), whereas substance P levels were higher at 48 h (0.55 vs 0.31 ng/mL; p < 0.05). Increased hydrogen sulfide and substance P levels in septic patients were associated with increased levels of inflammatory mediators - procalcitonin, C-reactive protein and interleukin-6.
These results provide evidence that higher circulating levels of hydrogen sulfide and substance P are associated with increased inflammatory response in patients with sepsis.
与具有相似疾病严重程度和器官功能障碍的非脓毒症患者相比，确定脓毒症患者循环中硫化氢和 P 物质水平的变化。
本研究包括 2015-16 年期间在新西兰克赖斯特彻奇医院重症监护病房的 23 例脓毒症患者和 14 例非脓毒症患者。从入院时开始采集血液样本，采集时间为 96 小时，采集时间点为 0 小时、12 小时、24 小时、48 小时、72 小时和 96 小时，并测量硫化氢、P 物质、降钙素原、C-反应蛋白、白细胞介素-6 和乳酸水平。
与非脓毒症患者相比，脓毒症患者的循环硫化氢和 P 物质水平较高。12 小时（1.45 对 0.75 μM；p < 0.05）和 24 小时（1.11 对 0.72 μM；p < 0.01）时，硫化氢水平显著升高，而 48 小时（0.55 对 0.31 ng/mL；p < 0.05）时，P 物质水平升高。脓毒症患者中硫化氢和 P 物质水平的升高与炎症介质-降钙素原、C-反应蛋白和白细胞介素-6 水平的升高有关。
这些结果提供了证据，表明循环中较高水平的硫化氢和 P 物质与脓毒症患者炎症反应的增加有关。
