沙特阿拉伯一家三级护理医院体外受精诊所就诊夫妇的乙型和丙型肝炎病毒流行率：与十年前的比较。

Hepatitis B and C virus prevalence in couples attending an in vitro fertilization clinic in a tertiary care hospital in Saudi Arabia: comparison with ten years earlier.

作者信息

Albadran Asma, Hibshi Ali, Saeed Bahjat, Coskun Serdar, Awartani Khalid Arab

机构信息

Dr. Asma Albadran, Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211,, Saudi Arabia, T: +966-11-442-7392, F: +966-11-442-7393,

出版信息

Ann Saudi Med. 2017 Jul-Aug;37(4):272-275. doi: 10.5144/0256-4947.2017.272.

DOI:10.5144/0256-4947.2017.272

PMID:28761024

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6150590/

Abstract

BACKGROUND

Viral hepatitis B (HBV) and C (HCV) are a major public health problem in Saudi Arabia. Recent data has indicated a major reduction in viral hepatitis prevalence in Saudi population. However, there is limited data for infertile Saudi couples.

OBJECTIVES

To determine the prevalence of HCV and HBV attending an in vitro fertilization (IVF) clinic in Saudi Arabia between 2012 and 2015 to compare with the prevalence 10 years earlier in the same center.

DESIGN

Retrospective prevalence study.

SETTING

Tertiary care center in Riyadh.

PATIENTS AND METHODS

Data on the prevalence of HBV and HCV was collected on all couples seen at the IVF unit between 2002-2005 and 2012-2015.

MAIN OUTCOME MEASURE(S): Prevalence of HBV and HCV.

RESULTS

In 4442 patients during 2002-2005 and 5747 patients during 2012-2015, the prevalence of HBV was significantly less in 2012-2015 compared with 2002-2005 (1.67% [97 patients] vs 4.7% [210 patients], P < .0001), respectively, but HCV prevalence was similar for the two periods (0.7% for both periods) (P=.887). The hepatitis B seroprevalence rate was higher in males compared to females during 2002-2005 (6.3% vs 3.1%) (P < .0001) and 2012-2015 (2.4% vs 1.1% ) (P < .0001), respectively.

CONCLUSION

The significant drop in HBV prevalence was most likely due to the introduction of the vaccination program in 1989, while reasons for HCV prevalence remaining unchanged are unclear.

LIMITATION

No data on confounding factors that may have affected the prevalence.

摘要

背景

乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）是沙特阿拉伯的一个主要公共卫生问题。近期数据表明沙特人群中病毒性肝炎患病率大幅下降。然而，关于沙特不育夫妇的数据有限。

目的

确定2012年至2015年期间在沙特阿拉伯一家体外受精（IVF）诊所就诊的丙型肝炎病毒和乙型肝炎病毒的患病率，并与该中心10年前的患病率进行比较。

设计

回顾性患病率研究。

地点

利雅得的三级医疗中心。

患者和方法

收集了2002 - 2005年和2012 - 2015年期间在体外受精科就诊的所有夫妇的HBV和HCV患病率数据。

主要观察指标

HBV和HCV的患病率。

结果

在2002 - 2005年期间的4442例患者和2012 - 2015年期间的5747例患者中，2012 - 2015年的HBV患病率显著低于2002 - 2005年（分别为1.67%[97例患者]对4.7%[210例患者]，P <.0001），但两个时期的HCV患病率相似（两个时期均为0.7%）（P =.887）。在2002 - 2005年期间（6.3%对3.1%）（P <.0001）和2012 - 2015年期间（2.4%对1.1%）（P <.0001），男性的乙肝血清流行率均高于女性。