Ellis John A, Gow Sheryl P, Lee Lindsey B, Lacoste Stacey, Ball Eileen C
Department of Veterinary Microbiology (Ellis, Lacoste), Department of Large Animal Clinical Sciences (Gow), Western College of Veterinary Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5B4; Thomas Crossroads Animal Hospital, 32 Oak Hill Blvd, Newman Georgia 30265, USA (Lee); Zoetis, 100 Campus Drive Florham Park, New Jersey 07932, USA (Ball).
Can Vet J. 2017 Aug;58(8):809-815.
In order to determine the comparative efficacy of injectable and intranasal vaccines to stimulate -reactive anamnestic antibodies, a trial was conducted using 144 adult household dogs of various breeds and ages, which had been previously administered intranasal vaccine approximately 12 months before enrollment. Dogs were randomized into 2 groups and blood, nasal swabs, and pharyngeal swabs were collected prior to the administration of single component vaccines intranasally or parenterally. Ten to 14 days later all dogs were resampled to measure changes in systemic and local antibody to There were no differences in the changes in -reactive serum IgG and nasal IgA between the groups, whereas intranasally vaccinated dogs had significantly higher -reactive serum IgA. These data indicate that both of the current generation of intranasal (modified-live) and injectable (acellular) vaccines can stimulate anamnestic local and systemic antibody responses in previously vaccinated, -seropositive adult household dogs.
为了确定注射用疫苗和鼻内疫苗刺激反应性记忆抗体的相对效力，使用144只不同品种和年龄的成年家养犬进行了一项试验，这些犬在入组前约12个月曾接种过鼻内疫苗。将犬随机分为2组，在鼻内或肠胃外接种单组分疫苗之前，采集血液、鼻拭子和咽拭子。10至14天后，对所有犬再次采样，以测量针对的全身和局部抗体的变化。两组之间反应性血清IgG和鼻内IgA的变化没有差异，而经鼻内接种疫苗的犬具有显著更高的反应性血清IgA。这些数据表明，当前一代鼻内（减毒活）疫苗和注射用（无细胞）疫苗均可在先前接种过、血清反应阳性的成年家养犬中刺激局部和全身记忆抗体反应。
