Scott-Garrard Maya M, Chiang Yu-Wei, David Frederic
Merial, Athens, Georgia, USA.
Vet Rec Open. 2018 Aug 13;5(1):e000285. doi: 10.1136/vetreco-2018-000285. eCollection 2018.
Three groups of approximately eight-week-old beagles were vaccinated once with 1 ml of placebo vaccine (oral, n=9), 1 ml of Recombitek® Oral Bordetella (oral, n=10) or 1 ml Nobivac® Intra-Trac (intranasal, 0.5 ml/nostril, n=10). Seven days after vaccination, the three groups were challenged with virulent via aerosolisation. Eight of nine dogs in the placebo group and no dogs in the Recombitek® Oral Bordetella or Nobivac® Intra-Trac vaccine groups developed spontaneous cough of two or more consecutive days (disease case definition). Dogs in the Recombitek® Oral Bordetella and Nobivac® Intra-Trac groups had a significantly lower incidence of disease (P<0.0001) with a 100 per cent preventable fraction. The study demonstrated that vaccination with either Recombitek® Oral Bordetella or Nobivac® Intra-Trac is effective in preventing disease seven days after vaccination when compared with dogs vaccinated with a placebo.
将三组约八周龄的比格犬分别接种1毫升安慰剂疫苗（口服，n = 9）、1毫升重组泰克®口服博德特氏菌疫苗（口服，n = 10）或1毫升诺必威®鼻内疫苗（鼻内接种，每侧鼻孔0.5毫升，n = 10），接种一次。接种疫苗七天后，对三组犬进行强毒气溶胶攻击。安慰剂组9只犬中有8只出现连续两天或更长时间的自发性咳嗽（疾病病例定义），重组泰克®口服博德特氏菌疫苗组和诺必威®鼻内疫苗组无犬出现此情况。重组泰克®口服博德特氏菌疫苗组和诺必威®鼻内疫苗组的疾病发病率显著较低（P<0.0001），预防率达100%。该研究表明，与接种安慰剂的犬相比，接种重组泰克®口服博德特氏菌疫苗或诺必威®鼻内疫苗在接种七天后对预防疾病有效。
