Sassi Asma, Bacha Dhouha, Talbi Ghofrane, Slama Sana Ben, Boughriba Rahma, Mzoughi Zeineb, Bouraoui Saadia, Lahmar Ahlem
Service d'Anatomie et Cytologie Pathologiques, Hôpital Mongi Slim, Sidi Daoued, 2046, Tunis, Tunisie.
Service de Chirurgie Générale, Hôpital Mongi Slim, Sidi Daoued, 2046, Tunis, Tunisie.
Pan Afr Med J. 2017 May 10;27:28. doi: 10.11604/pamj.2017.27.28.12251. eCollection 2017.
The detection of primary tumors synchronous with colorectal cancer has been the subject of multiple publications. This association can occur sporadically or fall under the framework of well defined clinical syndromes such as Lynch syndrome. Synchronous association of colorectal cancer (CRC) and renal cell carcinoma is rare. It is even more rare when renal cell carcinoma is of papillary origin, with only 2 cases reported in the literature. The association between CRC and renal cell carcinoma does not seem to be related to mismatch repair proteins (MMR) abnormality and does not include, up to now, any clinical syndrome. We report the case of a 69-year old woman with colorectal cancer associated with synchronous type 1 papillary renal cell carcinoma unexpectedly detected during screening for CRC. We here discuss the pathogenesis as well as the prognosis of this rarely described entity.
与结直肠癌同时发生的原发性肿瘤的检测一直是多篇文献的主题。这种关联可能是散发性的,也可能属于明确的临床综合征框架,如林奇综合征。结直肠癌(CRC)与肾细胞癌的同时发生较为罕见。当肾细胞癌为乳头状起源时则更为罕见,文献中仅报道过2例。CRC与肾细胞癌之间的关联似乎与错配修复蛋白(MMR)异常无关,且截至目前,并不包括任何临床综合征。我们报告了一例69岁女性患者,在CRC筛查期间意外发现患有与同步性1型乳头状肾细胞癌相关的结直肠癌。我们在此讨论这种罕见实体的发病机制及预后。