Olson Sara H, Satagopan Jaya, Xu Youming, Ling Lilan, Leong Siok, Orlow Irene, Saldia Amethyst, Li Peter, Nunes Pamela, Madonia Vincent, Allen Peter J, O'Reilly Eileen, Pamer Eric, Kurtz Robert C
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 485 Lexington Avenue, New York, NY, 10021, USA.
Department of Epidemiology and Public Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
Cancer Causes Control. 2017 Sep;28(9):959-969. doi: 10.1007/s10552-017-0933-8. Epub 2017 Jul 31.
Poor oral health appears to be a risk factor for pancreatic cancer, possibly implicating the oral microbiota. In this pilot study, we evaluated the characteristics of the oral microbiota in patients with pancreatic ductal adenocarcinoma (PDAC), intraductal papillary mucinous neoplasms (IPMN), and healthy controls.
Forty newly diagnosed PDAC patients, 39 IPMN patients, and 58 controls, excluding current smokers and users of antibiotics, provided saliva samples. Common oral bacterial species were comprehensively surveyed by sequencing of the 16S rRNA microbial genes. We obtained measures of diversity and the mean relative proportions of individual taxa. We explored the degree to which these measures differed according to respondent characteristics based on individual interviews.
PDAC cases did not differ in diversity measures from either controls or IPMN cases. PDAC cases had higher mean relative proportions of Firmicutes and related taxa, while controls had higher mean relative proportions of Proteobacteria and related taxa. Results were generally similar when comparing PDAC to IPMN cases. Among IPMNs and controls combined, younger individuals had higher levels of several taxa within the Proteobacteria. The only other variable consistently related to mean relative proportions was mouthwash use, with taxa within Firmicutes more common among users.
While there were no differences in diversity of the oral microbiota among these groups, there were differences in the mean relative proportions of some taxa. Characteristics of the oral microbiota are not associated with most measures of oral health.
口腔健康状况不佳似乎是胰腺癌的一个风险因素，这可能与口腔微生物群有关。在这项初步研究中，我们评估了胰腺导管腺癌（PDAC）、导管内乳头状黏液性肿瘤（IPMN）患者以及健康对照者的口腔微生物群特征。
40例新诊断的PDAC患者、39例IPMN患者和58例对照者（不包括当前吸烟者和抗生素使用者）提供了唾液样本。通过对16S rRNA微生物基因进行测序，全面调查了常见的口腔细菌种类。我们获得了多样性指标以及各个分类群的平均相对比例。我们根据个人访谈探索了这些指标因受访者特征而异的程度。
PDAC病例在多样性指标上与对照者或IPMN病例均无差异。PDAC病例中厚壁菌门及相关分类群的平均相对比例较高，而对照者中变形菌门及相关分类群的平均相对比例较高。将PDAC与IPMN病例进行比较时，结果总体相似。在IPMN患者和对照者的组合中，较年轻个体的变形菌门内几个分类群的水平较高。唯一与平均相对比例始终相关的其他变量是漱口水的使用情况，在使用者中厚壁菌门内的分类群更为常见。
虽然这些组之间口腔微生物群的多样性没有差异，但某些分类群的平均相对比例存在差异。口腔微生物群的特征与大多数口腔健康指标无关。
