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18 个月健康儿童访视时准确的自闭症筛查需要不同于 24 个月时的策略。

Accurate Autism Screening at the 18-Month Well-Child Visit Requires Different Strategies than at 24 Months.

机构信息

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Center for Promotion of Child Development through Primary Care, Baltimore, MD, 21210, USA.

出版信息

J Autism Dev Disord. 2017 Oct;47(10):3296-3310. doi: 10.1007/s10803-017-3231-0.

DOI:10.1007/s10803-017-3231-0
PMID:28762159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5711554/
Abstract

Accuracy of autism screening using M-CHAT plus the follow-up interview (M-CHAT/F) for children screened positive at 18-months was compared to screening at 24-months. Formal ASD testing was criterion for a community sample of M-CHAT positive children (n = 98), positive predictive value (PPV) was 0.40 for the M-CHAT and 0.58 for the M-CHAT/F. MCHAT/F PPV was 0.69 among children 20+ months compared to 0.36 for <20 months. Multivariate analyses incorporating data from the Ages and Stages Questionnaire, MacArthur-Bates Communicative Development Inventory, M-CHAT and M-CHAT/F results, and M-CHAT items suggest language variables carry greatest relative importance in contributing to an age-based algorithm with potential to improve PPV for toddlers <20 months to the same level as observed in older toddlers.

摘要

使用 M-CHAT 加随访访谈（M-CHAT/F）对 18 个月筛查阳性的儿童进行自闭症筛查的准确性与 24 个月筛查进行了比较。对 M-CHAT 阳性儿童（n=98）进行了社区样本的正式 ASD 测试，M-CHAT 的阳性预测值（PPV）为 0.40，M-CHAT/F 的阳性预测值为 0.58。与 <20 个月的儿童相比，20+个月的儿童的 MCHAT/F 的阳性预测值为 0.69。纳入来自年龄和阶段问卷、麦克阿瑟 - 贝茨交际发展量表、M-CHAT 和 M-CHAT/F 结果以及 M-CHAT 项目的数据的多变量分析表明，语言变量在根据年龄制定算法方面具有最大的相对重要性，有可能将 <20 个月的幼儿的阳性预测值提高到与较大年龄组相同的水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/5711554/e94337b9c7df/nihms896777f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/5711554/e94337b9c7df/nihms896777f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b77/5711554/e94337b9c7df/nihms896777f1.jpg

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