Khoomrung Sakda, Wanichthanarak Kwanjeera, Nookaew Intawat, Thamsermsang Onusa, Seubnooch Patcharamon, Laohapand Tawee, Akarasereenont Pravit
Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand.
Siriraj Metabolomics and Phenomics Center, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand.
Front Pharmacol. 2017 Jul 18;8:474. doi: 10.3389/fphar.2017.00474. eCollection 2017.
In recent years, interest in studies of traditional medicine in Asian and African countries has gradually increased due to its potential to complement modern medicine. In this review, we provide an overview of Thai traditional medicine (TTM) current development, and ongoing research activities of TTM related to metabolomics. This review will also focus on three important elements of systems biology analysis of TTM including analytical techniques, statistical approaches and bioinformatics tools for handling and analyzing untargeted metabolomics data. The main objective of this data analysis is to gain a comprehensive understanding of the system wide effects that TTM has on individuals. Furthermore, potential applications of metabolomics and systems medicine in TTM will also be discussed.
近年来,由于传统医学在补充现代医学方面的潜力,亚洲和非洲国家对传统医学研究的兴趣逐渐增加。在本综述中,我们概述了泰国传统医学(TTM)的当前发展以及与代谢组学相关的TTM正在进行的研究活动。本综述还将重点关注TTM系统生物学分析的三个重要要素,包括用于处理和分析非靶向代谢组学数据的分析技术、统计方法和生物信息学工具。这种数据分析的主要目的是全面了解TTM对个体的全系统影响。此外,还将讨论代谢组学和系统医学在TTM中的潜在应用。