Nurcahyanti Agustina Dwi Retno, Cokro Fonny, Wulanjati Martha P, Mahmoud Mona F, Wink Michael, Sobeh Mansour
Department of Pharmacy, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
Research Division for Natural Products Technology (BPTBA), National Research and Innovation Agency (BRIN), Yogyakarta, Indonesia.
Front Nutr. 2022 Jun 9;9:891339. doi: 10.3389/fnut.2022.891339. eCollection 2022.
The metabolic syndrome (MS) is a multifactorial syndrome associated with a significant economic burden and healthcare costs. MS management often requires multiple treatments (polydrug) to ameliorate conditions such as diabetes mellitus, insulin resistance, obesity, cardiovascular diseases, hypertension, and non-alcoholic fatty liver disease (NAFLD). However, various therapeutics and possible drug-drug interactions may also increase the risk of MS by altering lipid and glucose metabolism and promoting weight gain. In addition, the medications cause side effects such as nausea, flatulence, bloating, insomnia, restlessness, asthenia, palpitations, cardiac arrhythmias, dizziness, and blurred vision. Therefore, is important to identify and develop new safe and effective agents based on a multi-target approach to treat and manage MS. Natural products, such as curcumin, have multi-modalities to simultaneously target several factors involved in the development of MS. This review discusses the recent preclinical and clinical findings, and up-to-date meta-analysis from Randomized Controlled Trials regarding the effects of curcumin on MS, as well as the metabonomics and a pharma-metabolomics outlook considering curcumin metabolites, the gut microbiome, and environment for a complementary personalized prevention and treatment for MS management.
代谢综合征（MS）是一种多因素综合征，与巨大的经济负担和医疗费用相关。MS的管理通常需要多种治疗（多药联合）来改善诸如糖尿病、胰岛素抵抗、肥胖、心血管疾病、高血压和非酒精性脂肪性肝病（NAFLD）等病症。然而，各种治疗方法以及可能的药物相互作用也可能通过改变脂质和葡萄糖代谢以及促进体重增加而增加MS的风险。此外，这些药物会引起诸如恶心、肠胃胀气、腹胀、失眠、烦躁、乏力、心悸、心律失常、头晕和视力模糊等副作用。因此，基于多靶点方法来识别和开发新的安全有效的药物以治疗和管理MS非常重要。天然产物，如姜黄素，具有多模式作用，可同时针对参与MS发生发展的多个因素。本综述讨论了最近的临床前和临床研究结果，以及来自随机对照试验的关于姜黄素对MS影响的最新荟萃分析，以及考虑姜黄素代谢物、肠道微生物群和环境的代谢组学和药物代谢组学展望，以实现对MS管理的补充性个性化预防和治疗。
