Amer Bashar, Baidoo Edward E K
Lawrence Berkeley National Laboratory, Joint BioEnergy Institute, Emeryville, CA, United States.
Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.
Front Bioeng Biotechnol. 2021 Feb 23;9:613307. doi: 10.3389/fbioe.2021.613307. eCollection 2021.
Biomanufacturing is a key component of biotechnology that uses biological systems to produce bioproducts of commercial relevance, which are of great interest to the energy, material, pharmaceutical, food, and agriculture industries. Biotechnology-based approaches, such as synthetic biology and metabolic engineering are heavily reliant on "omics" driven systems biology to characterize and understand metabolic networks. Knowledge gained from systems biology experiments aid the development of synthetic biology tools and the advancement of metabolic engineering studies toward establishing robust industrial biomanufacturing platforms. In this review, we discuss recent advances in "omics" technologies, compare the pros and cons of the different "omics" technologies, and discuss the necessary requirements for carrying out multi-omics experiments. We highlight the influence of "omics" technologies on the production of biofuels and bioproducts by metabolic engineering. Finally, we discuss the application of "omics" technologies to agricultural and food biotechnology, and review the impact of "omics" on current COVID-19 research.
生物制造是生物技术的一个关键组成部分，它利用生物系统生产具有商业价值的生物产品，这些产品对能源、材料、制药、食品和农业产业具有重大意义。基于生物技术的方法，如合成生物学和代谢工程，严重依赖于“组学”驱动的系统生物学来表征和理解代谢网络。从系统生物学实验中获得的知识有助于合成生物学工具的开发以及代谢工程研究朝着建立强大的工业生物制造平台推进。在这篇综述中，我们讨论了“组学”技术的最新进展，比较了不同“组学”技术的优缺点，并讨论了进行多组学实验的必要条件。我们强调了“组学”技术对通过代谢工程生产生物燃料和生物产品的影响。最后，我们讨论了“组学”技术在农业和食品生物技术中的应用，并综述了“组学”对当前新冠病毒研究的影响。
