Glaucoma Research and Diagnostic Center, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Acta Ophthalmol. 2018 Mar;96(2):e237-e241. doi: 10.1111/aos.13530. Epub 2017 Aug 3.
To investigate the effects of an antioxidant dietary supplement that includes Ginkgo biloba, on retinal and retrobulbar blood flow in patients with open-angle glaucoma (OAG).
Forty-five patients with confirmed OAG were enroled in a randomized, double blinded, placebo-controlled cross-over study. Baseline and postadministration measurements of intraocular pressure (IOP), ocular perfusion pressure (OPP), retrobulbar blood flow, and retinal capillary blood flow were non-invasively measured (ultrasound and laser Doppler modalities, respectively) before and one month after antioxidant nutraceuticals and placebo administration. Changes in measurements between the active supplement and placebo arms were evaluated using paired t-tests, with p < 0.05 considered statistically significant.
Antioxidant supplementation produced a statistically significant increase in peak systolic and/or end diastolic blood flow velocities in all retrobulbar blood vessels compared to placebo. Vascular resistance was also reduced in central retinal and nasal short posterior ciliary arteries following antioxidant administration. Additionally, antioxidant supplementation increased superior and inferior temporal retinal capillary mean blood flow and the ratio of active to non-active retina capillaries compared to placebo.
One-month oral administration of antioxidants produced increases in biomarkers of ocular blood flow within retinal and retrobulbar vascular beds in patients with OAG.
研究一种包含银杏叶的抗氧化膳食补充剂对开角型青光眼（OAG）患者视网膜和球后血流的影响。
45 名确诊为 OAG 的患者参与了一项随机、双盲、安慰剂对照的交叉研究。在抗氧化营养补充剂和安慰剂给药前和给药后一个月，分别使用超声和激光多普勒模式非侵入性测量眼压（IOP）、眼灌注压（OPP）、球后血流和视网膜毛细血管血流的基线和给药后测量值。使用配对 t 检验评估活性补充剂和安慰剂臂之间测量值的变化，p<0.05 被认为具有统计学意义。
与安慰剂相比，抗氧化补充剂使所有球后血管的收缩期峰值血流速度和/或舒张末期血流速度均有统计学显著增加。抗氧化剂给药后，视网膜中央和鼻侧短睫状后动脉的血管阻力也降低。此外，与安慰剂相比，抗氧化补充剂增加了上、下颞侧视网膜毛细血管平均血流以及活跃和非活跃视网膜毛细血管的比例。
在 OAG 患者中，口服抗氧化剂一个月可增加视网膜和球后血管床的眼血流生物标志物。
