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用于骨组织工程的工程化蜘蛛丝蛋白基复合材料的生物矿化

Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering.

作者信息

Hardy John G, Torres-Rendon Jose Guillermo, Leal-Egaña Aldo, Walther Andreas, Schlaad Helmut, Cölfen Helmut, Scheibel Thomas R

机构信息

Lehrstuhl Biomaterialien, Universität Bayreuth, Universitätsstraße 30, Bayreuth 95447, Germany.

DWI Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, Aachen 52056, Germany.

出版信息

Materials (Basel). 2016 Jul 11;9(7):560. doi: 10.3390/ma9070560.

DOI:10.3390/ma9070560
PMID:28773681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456849/
Abstract

Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate--poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.

摘要

基于可生物降解聚酯的材料，如聚对苯二甲酸丁二醇酯（PBT）或聚对苯二甲酸丁二醇酯-聚（亚烷基二醇）对苯二甲酸酯（PBTAT），作为骨组织工程的促再生支架具有潜在应用价值。本文报道了由PBT或PBTAT与一种工程蜘蛛丝蛋白（eADF4(C16)）组成的薄膜的制备，该蛋白具有多个能够结合钙离子并促进其与碳酸钙或磷酸钙进行生物矿化的羧酸基团。在磷酸钙矿化薄膜上培养的人间充质干细胞显示出碱性磷酸酶活性水平增强，这表明此类复合材料在骨组织工程中具有潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/efc3515301ce/materials-09-00560-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/8137b18f325a/materials-09-00560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/2e3fd1ffea7a/materials-09-00560-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/182bd9f94908/materials-09-00560-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/efc3515301ce/materials-09-00560-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/8137b18f325a/materials-09-00560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/2e3fd1ffea7a/materials-09-00560-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/182bd9f94908/materials-09-00560-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eeb4/5456849/efc3515301ce/materials-09-00560-g004.jpg

相似文献

[1]
Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering.

Materials (Basel). 2016-7-11

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
Evaluation of two biodegradable polymeric systems as substrates for bone tissue engineering.

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[10]
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引用本文的文献

[1]
Sustainable Hydrogels for Medical Applications: Biotechnological Innovations Supporting One Health.

Gels. 2025-7-21

[2]
Biomineral-Based Composite Materials in Regenerative Medicine.

Int J Mol Sci. 2024-6-2

[3]
Synthetic Calcium-Phosphate Materials for Bone Grafting.

Polymers (Basel). 2023-9-19

[4]
A Review of the Role of Tendon Stem Cells in Tendon-Bone Regeneration.

Med Sci Monit. 2023-9-16

[5]
Recombinant Proteins-Based Strategies in Bone Tissue Engineering.

Biomolecules. 2021-12-21

[6]
Spidroin-Based Biomaterials in Tissue Engineering: General Approaches and Potential Stem Cell Therapies.

Stem Cells Int. 2021-12-20

[7]
Silk-Based Materials for Hard Tissue Engineering.

Materials (Basel). 2021-2-1

[8]
Spider Silk for Tissue Engineering Applications.

Molecules. 2020-2-8

[9]
Delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from MaSp1 and MaSp2 proteins.

Nanomedicine (Lond). 2018-1-17

本文引用的文献

[1]
Enzymatic Degradation of Films, Particles, and Nonwoven Meshes Made of a Recombinant Spider Silk Protein.

ACS Biomater Sci Eng. 2015-4-13

[2]
Functional Coatings or Films for Hard-Tissue Applications.

Materials (Basel). 2010-7-9

[3]
Preclinical Performance of Novel Biodegradable, Electrospun Poly(lactic acid) and Poly(lactic-co-glycolic acid) Nanocomposites: A Review.

Materials (Basel). 2015-8-3

[4]
Mineralized Collagen: Rationale, Current Status, and Clinical Applications.

Materials (Basel). 2015-7-24

[5]
Cartilage Tissue Engineering with Silk Fibroin Scaffolds Fabricated by Indirect Additive Manufacturing Technology.

Materials (Basel). 2014-3-13

[6]
Calcium Orthophosphate-Based Bioceramics.

Materials (Basel). 2013-9-6

[7]
Expression of Concern: Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine. Materials 2009, 2, 1975-2045.

Materials (Basel). 2016-9-2

[8]
Recombinant protein blends: silk beyond natural design.

Curr Opin Biotechnol. 2016-6

[9]
Incorporation of Human Recombinant Tropoelastin into Silk Fibroin Membranes with the View to Repairing Bruch's Membrane.

J Funct Biomater. 2015-9-16

[10]
Supracolloidal Assemblies as Sacrificial Templates for Porous Silk-Based Biomaterials.

Int J Mol Sci. 2015-8-28

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