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使用由 MaSp1 和 MaSp2 蛋白衍生的生物工程蛛丝制成的球体来输送化疗药物。

Delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from MaSp1 and MaSp2 proteins.

机构信息

Chair of Medical Biotechnology, Poznan University of Medical Sciences, 61-688 Poznan, Poland.

NanoBioMedical Centre, Adam Mickiewicz University, 61-614 Poznan, Poland.

出版信息

Nanomedicine (Lond). 2018 Feb;13(4):439-454. doi: 10.2217/nnm-2017-0276. Epub 2018 Jan 17.

DOI:10.2217/nnm-2017-0276
PMID:29338625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5810845/
Abstract

AIM: Analysis of the properties and chemotherapeutics delivery potential of spheres made of bioengineered spider silks MS1 and MS2. MATERIALS & METHODS: MS1 and MS2 derived from Nephila clavipes dragline silks - MaSp1 and MaSp2, respectively - formed spheres that were compared in terms of physicochemical properties, cytotoxicity and loading/release of chemotherapeutics. RESULTS: MS2 spheres were more dispersed, smaller, of solid core, of higher beta-sheet structure content, and of opposite (negative) charge than MS1 spheres. Preloaded MS2 showed greater applicability for mitoxantrone, while postloaded for etoposide delivery compared with MS1 spheres. However, MS1 spheres were a better choice for doxorubicin delivery than MS2. CONCLUSION: Bioengineered silks can be tailored to develop a system with optimal drug loading and release properties.

摘要

目的：分析由生物工程蛛丝 MS1 和 MS2 制成的球体的特性和化疗药物传递潜力。

材料与方法：MS1 和 MS2 分别来自金蛛牵引丝 MaSp1 和 MaSp2，形成了球体，从理化性质、细胞毒性以及化疗药物的负载/释放方面对它们进行了比较。

结果：MS2 球体更分散、更小、为实心核、β-折叠结构含量更高、带相反（负）电荷，而 MS1 球体则相反。与 MS1 球体相比，载有米托蒽醌的 MS2 球体具有更高的适用性，而载有依托泊苷的 MS1 球体则具有更高的适用性。然而，MS1 球体在阿霉素传递方面优于 MS2 球体。

结论：生物工程丝可以进行定制，以开发出具有最佳药物负载和释放特性的系统。

相似文献

[1]
Delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from MaSp1 and MaSp2 proteins.

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
In vivo study of the immune response to bioengineered spider silk spheres.

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[9]
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[10]
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本文引用的文献

[1]
Micromechanical characterization of spider silk particles.

Biomater Sci. 2013-11-1

[2]
Blending two bioengineered spider silks to develop cancer targeting spheres.

J Mater Chem B. 2017-4-28

[3]
Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering.

Materials (Basel). 2016-7-11

[4]
Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment.

Acta Biomater. 2017-9-1

[5]
Cellular uptake of drug loaded spider silk particles.

Biomater Sci. 2016-9-20

[6]
Surface-Functionalized Silk Fibroin Films as a Platform To Guide Neuron-like Differentiation of Human Mesenchymal Stem Cells.

ACS Appl Mater Interfaces. 2016-8-23

[7]
The method of purifying bioengineered spider silk determines the silk sphere properties.

Sci Rep. 2016-6-17

[8]
Pigmented Silk Nanofibrous Composite for Skeletal Muscle Tissue Engineering.

Adv Healthc Mater. 2016-3-22

[9]
Silk as an innovative biomaterial for cancer therapy.

Rep Pract Oncol Radiother. 2014-12-18

[10]
Biomimetic fibers made of recombinant spidroins with the same toughness as natural spider silk.

Adv Mater. 2015-2-16

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