• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

钛表面的两级微米至纳米级分层二氧化钛纳米层

Two-Level Micro-to-Nanoscale Hierarchical TiO₂ Nanolayers on Titanium Surface.

作者信息

Zemtsova Elena G, Arbenin Andrei Yu, Valiev Ruslan Z, Orekhov Evgeny V, Semenov Valentin G, Smirnov Vladimir M

机构信息

Institute of Chemistry, Saint Petersburg State University, Universitetskii pr.26, St. Petersburg 198504, Russia.

出版信息

Materials (Basel). 2016 Dec 13;9(12):1010. doi: 10.3390/ma9121010.

DOI:10.3390/ma9121010
PMID:28774129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5456974/
Abstract

Joint replacement is being actively developed within modern orthopedics. One novel material providing fast implantation is bioactive coatings. The synthesis of targeted nanocoatings on metallic nanotitanium surface is reported in this paper. TiO₂-based micro- and nanocoatings were produced by sol-gel synthesis using dip-coating technology with subsequent fast (shock) drying in hot plate mode at 400 °C. As a result of shock drying, the two-level hierarchical TiO₂ nanolayer on the nanotitanium was obtained. This two-level hierarchy includes nanorelief of porous xerogel and microrelief of the micron-sized "defect" network (a crack network). The thickness of TiO₂ nanolayers was controlled by repeating dip-coating process the necessary number of times after the first layer deposition. The state of the MS3T3-E1 osteoblast cell line (young cells that form bone tissue) on the two-level hierarchical surface has been studied. Particularly, adhesion character, adhesion time and morphology have been studied. The reported results may serve the starting point for the development of novel bioactive coatings for bone and teeth implants.

摘要

关节置换术在现代骨科学领域正得到积极发展。一种能够实现快速植入的新型材料是生物活性涂层。本文报道了在金属纳米钛表面合成靶向纳米涂层的方法。基于TiO₂的微米和纳米涂层通过溶胶 - 凝胶合成法制备，采用浸涂技术，随后在400°C的热板模式下进行快速（冲击）干燥。经过冲击干燥，在纳米钛上获得了两级分层的TiO₂纳米层。这种两级分层包括多孔干凝胶的纳米微凸和微米级“缺陷”网络（裂纹网络）的微凸。TiO₂纳米层的厚度通过在第一层沉积后重复浸涂过程所需的次数来控制。研究了两级分层表面上MS3T3 - E1成骨细胞系（形成骨组织的年轻细胞）的状态。特别是，研究了其粘附特性、粘附时间和形态。所报道的结果可能为开发用于骨和牙齿植入物的新型生物活性涂层提供起点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/d424e30b74f2/materials-09-01010-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/ee8788d5ebd9/materials-09-01010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/701e18d71ce9/materials-09-01010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/403124b9106d/materials-09-01010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/7f9c553e5538/materials-09-01010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/23e3a6c840a9/materials-09-01010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/e05fbccf8c93/materials-09-01010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/41ed9f7373d2/materials-09-01010-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/e4a0ba80f7f5/materials-09-01010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/9299164440c0/materials-09-01010-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/ffe6efe91487/materials-09-01010-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/1afe4ff754ae/materials-09-01010-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/887f070798eb/materials-09-01010-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/9a6d865af4fb/materials-09-01010-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/3c8dbd1a8cf3/materials-09-01010-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/d424e30b74f2/materials-09-01010-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/ee8788d5ebd9/materials-09-01010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/701e18d71ce9/materials-09-01010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/403124b9106d/materials-09-01010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/7f9c553e5538/materials-09-01010-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/23e3a6c840a9/materials-09-01010-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/e05fbccf8c93/materials-09-01010-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/41ed9f7373d2/materials-09-01010-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/e4a0ba80f7f5/materials-09-01010-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/9299164440c0/materials-09-01010-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/ffe6efe91487/materials-09-01010-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/1afe4ff754ae/materials-09-01010-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/887f070798eb/materials-09-01010-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/9a6d865af4fb/materials-09-01010-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/3c8dbd1a8cf3/materials-09-01010-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7028/5456974/d424e30b74f2/materials-09-01010-g015.jpg

相似文献

1
Two-Level Micro-to-Nanoscale Hierarchical TiO₂ Nanolayers on Titanium Surface.钛表面的两级微米至纳米级分层二氧化钛纳米层
Materials (Basel). 2016 Dec 13;9(12):1010. doi: 10.3390/ma9121010.
2
Bioactive Coating with Two-Layer Hierarchy of Relief Obtained by Sol-Gel Method with Shock Drying and Osteoblast Response of Its Structure.
Nanomaterials (Basel). 2017 Oct 13;7(10):323. doi: 10.3390/nano7100323.
3
Sol-Gel Fabricated Tio₂ Coating on Titanium Surface Promoted In Vitro Osteoblasts Differentiation.溶胶-凝胶法制备的钛表面二氧化钛涂层促进体外成骨细胞分化。
Eur J Prosthodont Restor Dent. 2019 Nov 28;27(4):145-153. doi: 10.1922/EJPRD_01919Angwarawong09.
4
Titania-hydroxyapatite nanocomposite coatings support human mesenchymal stem cells osteogenic differentiation.载有纳米羟基磷灰石的二氧化钛复合涂层支持人骨髓间充质干细胞成骨分化。
J Biomed Mater Res A. 2011 Sep 15;98(4):576-88. doi: 10.1002/jbm.a.32964. Epub 2011 Jun 23.
5
Osteoblast responses to different oxide coatings produced by the sol-gel process on titanium substrates.成骨细胞对通过溶胶-凝胶工艺在钛基底上制备的不同氧化物涂层的反应。
Acta Biomater. 2008 Sep;4(5):1506-17. doi: 10.1016/j.actbio.2008.03.012. Epub 2008 Apr 7.
6
A bioactive coating of a silica xerogel/chitosan hybrid on titanium by a room temperature sol-gel process.室温溶胶-凝胶法在钛上制备二氧化硅/壳聚糖杂化的生物活性涂层。
Acta Biomater. 2010 Jan;6(1):302-7. doi: 10.1016/j.actbio.2009.06.024. Epub 2009 Jun 14.
7
Formation of Micro- and Nanostructures on the Nanotitanium Surface by Chemical Etching and Deposition of Titania Films by Atomic Layer Deposition (ALD).通过化学蚀刻在纳米钛表面形成微纳结构，并通过原子层沉积（ALD）法沉积二氧化钛薄膜。
Materials (Basel). 2015 Dec 2;8(12):8366-8377. doi: 10.3390/ma8125460.
8
Initial responses of human osteoblasts to sol-gel modified titanium with hydroxyapatite and titania composition.人成骨细胞对含羟基磷灰石和二氧化钛成分的溶胶-凝胶改性钛的初始反应。
Acta Biomater. 2006 Sep;2(5):547-56. doi: 10.1016/j.actbio.2006.05.005. Epub 2006 Jul 10.
9
Atomic layer deposition-A novel method for the ultrathin coating of minitablets.原子层沉积——一种用于微型片剂超薄包衣的新方法。
Int J Pharm. 2017 Oct 5;531(1):47-58. doi: 10.1016/j.ijpharm.2017.08.010. Epub 2017 Aug 9.
10
The enhanced characteristics of osteoblast adhesion to photofunctionalized nanoscale TiO2 layers on biomaterials surfaces.生物材料表面光功能化纳米 TiO2 层增强成骨细胞黏附的特性。
Biomaterials. 2010 May;31(14):3827-39. doi: 10.1016/j.biomaterials.2010.01.133. Epub 2010 Feb 13.

引用本文的文献

1
A Feasible Strategy for Fabricating Surface Porous Network in Fe-Si Ribbons.在铁硅带材中制造表面多孔网络的可行策略。
Materials (Basel). 2018 Apr 29;11(5):701. doi: 10.3390/ma11050701.
2
Improved osseointegration properties of hierarchical microtopographic/nanotopographic coatings fabricated on titanium implants.在钛植入物上制备的具有分级微形貌/纳米形貌的涂层可改善其骨整合性能。
Int J Nanomedicine. 2018 Apr 11;13:2175-2188. doi: 10.2147/IJN.S161292. eCollection 2018.
3
Bioactive Coating with Two-Layer Hierarchy of Relief Obtained by Sol-Gel Method with Shock Drying and Osteoblast Response of Its Structure.

本文引用的文献

1
Formation of Micro- and Nanostructures on the Nanotitanium Surface by Chemical Etching and Deposition of Titania Films by Atomic Layer Deposition (ALD).通过化学蚀刻在纳米钛表面形成微纳结构，并通过原子层沉积（ALD）法沉积二氧化钛薄膜。
Materials (Basel). 2015 Dec 2;8(12):8366-8377. doi: 10.3390/ma8125460.
2
Fabrication of TiO2-strontium loaded CaSiO3/biopolymer coatings with enhanced biocompatibility and corrosion resistance by controlled release of minerals for improved orthopedic applications.通过控制矿物质释放制备具有增强生物相容性和耐腐蚀性的负载二氧化钛锶的硅酸钙/生物聚合物涂层，用于改善骨科应用。
J Mech Behav Biomed Mater. 2016 Jul;60:476-491. doi: 10.1016/j.jmbbm.2016.02.021. Epub 2016 Mar 3.
3
Nanomaterials (Basel). 2017 Oct 13;7(10):323. doi: 10.3390/nano7100323.
Characterization and preosteoblastic behavior of hydroxyapatite-deposited nanotube surface of titanium prepared by anodization coupled with alternative immersion method.
采用阳极氧化结合交替浸没法制备的羟基磷灰石沉积纳米管表面钛的表征及成骨细胞行为。
J Biomed Mater Res B Appl Biomater. 2012 Nov;100(8):2122-30. doi: 10.1002/jbm.b.32777. Epub 2012 Jul 30.
4
Effect of titanium implant surface nanoroughness and calcium phosphate low impregnation on bone cell activity in vitro.钛种植体表面纳米粗糙度及磷酸钙低浸渍对体外骨细胞活性的影响
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb;109(2):217-24. doi: 10.1016/j.tripleo.2009.09.007.
5
The anatase phase of nanotopography titania plays an important role on osteoblast cell morphology and proliferation.纳米拓扑二氧化钛的锐钛矿相在成骨细胞形态和增殖方面起着重要作用。
J Mater Sci Mater Med. 2008 Nov;19(11):3465-72. doi: 10.1007/s10856-008-3505-3. Epub 2008 Jul 1.
6
Plasma-controlled nanocrystallinity and phase composition of TiO2: a smart way to enhance biomimetic response.等离子体控制的TiO₂纳米结晶度和相组成：增强仿生响应的巧妙方法。
J Biomed Mater Res A. 2007 May;81(2):453-64. doi: 10.1002/jbm.a.30987.
7
Plasmon-assisted chemical vapor deposition.等离子体辅助化学气相沉积
Nano Lett. 2006 Nov;6(11):2592-7. doi: 10.1021/nl062061m.
8
Synthesis of titanium dioxide (TiO2) nanomaterials.二氧化钛（TiO₂）纳米材料的合成。
J Nanosci Nanotechnol. 2006 Apr;6(4):906-25. doi: 10.1166/jnn.2006.160.
9
Osteoprogenitor response to defined topographies with nanoscale depths.骨祖细胞对具有纳米级深度的特定形貌的反应。
Biomaterials. 2006 Mar;27(8):1306-15. doi: 10.1016/j.biomaterials.2005.08.028. Epub 2005 Sep 6.
10
Coating of titanium implants with type-I collagen.用I型胶原蛋白包覆钛植入物。
J Orthop Res. 2004 Sep;22(5):1025-34. doi: 10.1016/j.orthres.2004.02.011.