Ambagtsheer Rachel, Visvanathan Renuka, Cesari Matteo, Yu Solomon, Archibald Mandy, Schultz Timothy, Karnon Jonathon, Kitson Alison, Beilby Justin
National Health and Medical Research Council of Australia Centre of Research Excellence Frailty Transdisciplinary Research to Achieve Healthy Ageing, Adelaide, South Australia, Australia.
Torrens University Australia, Adelaide, South Australia, Australia.
BMJ Open. 2017 Aug 3;7(8):e016663. doi: 10.1136/bmjopen-2017-016663.
Frailty is one of the most challenging aspects of population ageing due to its association with increased risk of poor health outcomes and quality of life. General practice provides an ideal setting for the prevention and management of frailty via the implementation of preventive measures such as early identification through screening.
Our study will evaluate the feasibility, acceptability and diagnostic test accuracy of several screening instruments in diagnosing frailty among community-dwelling Australians aged 75+ years who have recently made an appointment to see their general practitioner (GP). We will recruit 240 participants across 2 general practice sites within South Australia. We will invite eligible patients to participate and consent to the study via mail. Consenting participants will attend a screening appointment to undertake the index tests: 2 self-reported (Reported Edmonton Frail Scale and Kihon Checklist) and 5 (Frail Scale, Groningen Frailty Index, Program on Research for Integrating Services for the Maintenance of Autonomy (PRISMA-7), Edmonton Frail Scale and Gait Speed Test) administered by a practice nurse (a Registered Nurse working in general practice). We will randomise test order to reduce bias. Psychosocial measures will also be collected via questionnaire at the appointment. A blinded researcher will then administer two reference standards (the Frailty Phenotype and Adelaide Frailty Index). We will determine frailty by a cut-point of 3 of 5 criteria for the Phenotype and 9 of 42 items for the AFI. We will determine accuracy by analysis of sensitivity, specificity, predictive values and likelihood ratios. We will assess feasibility and acceptability by: 1) collecting data about the instruments prior to collection; 2) interviewing screeners after data collection; 3) conducting a pilot survey with a 10% sample of participants.
The Torrens University Higher Research Ethics Committee has approved this study. We will disseminate findings via publication in peer-reviewed journals and presentation at relevant conferences.
衰弱是人口老龄化最具挑战性的方面之一,因为它与健康状况不佳和生活质量下降的风险增加有关。全科医疗通过实施预防措施,如通过筛查进行早期识别,为衰弱的预防和管理提供了理想的环境。
我们的研究将评估几种筛查工具在诊断75岁及以上居住在社区且最近预约看全科医生(GP)的澳大利亚人中衰弱的可行性、可接受性和诊断测试准确性。我们将在南澳大利亚的2个全科医疗站点招募240名参与者。我们将通过邮件邀请符合条件的患者参与并同意参加研究。同意参与的参与者将参加一次筛查预约,进行指标测试:2项自我报告测试(埃德蒙顿衰弱量表报告版和基宏检查表)以及由一名执业护士(在全科医疗工作的注册护士)进行的5项测试(衰弱量表、格罗宁根衰弱指数、维持自主性综合服务研究项目(PRISMA - 7)、埃德蒙顿衰弱量表和步态速度测试)。我们将随机安排测试顺序以减少偏差。在预约时还将通过问卷收集社会心理测量数据。然后,一名盲法研究人员将实施两项参考标准(衰弱表型和阿德莱德衰弱指数)。我们将根据表型的5项标准中的3项以及AFI的42项中的9项的切点来确定衰弱。我们将通过分析敏感性、特异性、预测值和似然比来确定准确性。我们将通过以下方式评估可行性和可接受性:1)在数据收集之前收集有关工具的数据;2)在数据收集后对筛查人员进行访谈;3)对10%的参与者样本进行试点调查。
托伦斯大学高等研究伦理委员会已批准本研究。我们将通过在同行评审期刊上发表以及在相关会议上展示来传播研究结果。