Steardo L, Barone P, Hunnicutt E
Acta Neurol Scand. 1986 Aug;74(2):140-4. doi: 10.1111/j.1600-0404.1986.tb04640.x.
The effect of carbamazepine treatment on CSF-somatostatin-like immunoreactivity (SLI) in patients suffering from temporal lobe epilepsy was investigated. A baseline lumbar puncture was performed on 12 patients and 10 normal volunteers. A second tap was repeated only in patients when they were on peak of carbamazepine concentration for 10 days. Levels of CSF-SLI were measured by RIA. No significant differences were found in CSF-SLI basal concentrations between epileptics and controls, whereas a significant decrease (p less than .0002 Duncan's multiple range test) of CSF peptide levels occurred in 9 of 12 patients under medication. Although the neural mechanism through which carbamazepine lowers CSF-SLI is still unknown, the results of the present study suggest that the reported effect might be part of the apparatus by which carbamazepine exerts its anticonvulsant action.
研究了卡马西平治疗对颞叶癫痫患者脑脊液中生长抑素样免疫活性（SLI）的影响。对12例患者和10名正常志愿者进行了基线腰椎穿刺。仅在患者卡马西平浓度达到峰值10天时对患者重复进行第二次穿刺。通过放射免疫分析法测定脑脊液SLI水平。癫痫患者和对照组之间脑脊液SLI基础浓度未发现显著差异，而在12例接受药物治疗的患者中有9例脑脊液肽水平显著降低（p小于0.0002，邓肯多重极差检验）。尽管卡马西平降低脑脊液SLI的神经机制尚不清楚，但本研究结果表明，所报道的这种作用可能是卡马西平发挥抗惊厥作用机制的一部分。
