Campos-Magdaleno María, Facal David, Lojo-Seoane Cristina, Pereiro Arturo X, Juncos-Rabadán Onésimo
Department of Developmental and Educational Psychology, University of Santiago de CompostelaSantiago de Compostela, Spain.
Front Psychol. 2017 Jul 20;8:1231. doi: 10.3389/fpsyg.2017.01231. eCollection 2017.
To identify learning effects and meaningful changes in amnestic mild cognitive impairment (aMCI) at a follow-up assessment. The Spanish version of the California Verbal Learning Test (CVLT) was administered to a sample of 274 adults of age over 50 years with subjective memory complains (SMC), including single and multiple domain aMCI groups and participants with SMC but without cognitive impairment (SMC group). The Wilcoxon test was used to compare results at baseline and after 18 months in short and long recall, and standardized regression-based (SRB) methods were used to study meaningful changes. Scores were significantly higher at follow-up for short and long-delayed recall in all groups indicating generalized practice effect. SRB scores indicated a significant decline in recall in a higher proportion of participants with aMCI than in SMC group. Patients with multiple and single domain aMCI benefit from practice in a verbal learning memory test. The SRB approach revealed a higher incidence of meaningful decline in short and long-delay recall and recognition in the aMCI groups than in the SMC group. Specifically, compared to SMC participants, single-domain aMCI individuals declined in a higher proportion in all measures, and multiple-domain aMCI individuals in long delay free recall.
在随访评估中识别遗忘型轻度认知障碍（aMCI）的学习效应和有意义的变化。对274名年龄超过50岁、有主观记忆主诉（SMC）的成年人样本进行了加利福尼亚语言学习测试（CVLT）的西班牙语版本测试，其中包括单领域和多领域aMCI组以及有SMC但无认知障碍的参与者（SMC组）。采用Wilcoxon检验比较基线和18个月后短期和长期回忆的结果，并使用基于标准化回归（SRB）的方法研究有意义的变化。所有组在随访时短期和长期延迟回忆的分数均显著更高，表明存在普遍的练习效应。SRB分数表明，与SMC组相比，aMCI参与者中有更高比例的人回忆能力显著下降。多领域和单领域aMCI患者在语言学习记忆测试中受益于练习。SRB方法显示，与SMC组相比，aMCI组在短期和长期延迟回忆及识别方面有意义下降的发生率更高。具体而言，与SMC参与者相比，单领域aMCI个体在所有测量指标上下降的比例更高，多领域aMCI个体在长期延迟自由回忆方面下降的比例更高。
