Negro Roberto, Colosimo Ermenegildo, Greco Gabriele
Division of Endocrinology, "V. Fazzi" Hospital, Piazza F. Muratore, 73100 Lecce, Italy.
Division of Pathology, "V. Fazzi" Hospital, Piazza F. Muratore, 73100 Lecce, Italy.
J Thyroid Res. 2017;2017:9536479. doi: 10.1155/2017/9536479. Epub 2017 Jul 9.
Thyroid cysts are usually benign lesions that when voluminous may induce cosmetic concerns or local discomfort. Percutaneous ethanol injection (PEI) has been demonstrated to be effective for shrinkage of such cysts. In this retrospective study, we evaluated the efficacy, pain perception, and health-related quality of life (HRQL) in patients submitted to PEI for pure cystic lesions. We reviewed the data of 101 patients who underwent ≤3 PEI. In the whole group of patients, the volume reduction was 66% after the first, 74.4% after the second, and 79.4% after the third PEI treatment. 55.4% had a cystic volume ≤ 10 ml; 85.7% of cysts ≤ 10 ml were cured by just one PEI. The number of PEI was significantly higher in the >30.0 ml group; this latter group obtained the smallest percent reduction versus baseline after the first PEI when compared with smaller cysts. The sensation of pain reported during PEI was absent in 78.3% of cases, and HRQL significantly improved from pre- to the posttreatment. PEI is a safe and effective technique for pure cystic lesions. In addition, HRQL significantly improves, providing a further support for this procedure.
甲状腺囊肿通常是良性病变，囊肿较大时可能会引起外观问题或局部不适。经皮乙醇注射（PEI）已被证明对这类囊肿的缩小有效。在这项回顾性研究中，我们评估了接受PEI治疗单纯性囊性病变患者的疗效、疼痛感受以及健康相关生活质量（HRQL）。我们回顾了101例接受≤3次PEI治疗患者的数据。在整个患者组中，第一次PEI治疗后囊肿体积减少66%，第二次后减少74.4%，第三次后减少79.4%。55.4%的患者囊肿体积≤10 ml；85.7%体积≤10 ml的囊肿仅通过一次PEI治疗即治愈。囊肿体积>30.0 ml组的PEI治疗次数显著更多；与较小囊肿相比，该组在第一次PEI治疗后相对于基线的缩小百分比最小。78.3%的患者在PEI治疗期间未报告疼痛感觉，HRQL从治疗前到治疗后显著改善。PEI是治疗单纯性囊性病变的一种安全有效的技术。此外，HRQL显著改善，为该治疗方法提供了进一步的支持。
