• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent.

作者信息

Czub M, Braig H R, Blode H, Diringer H

出版信息

Arch Virol. 1986;91(3-4):383-6. doi: 10.1007/BF01314297.

DOI:10.1007/BF01314297
PMID:2877648
Abstract

Scrapie-associated fibrils (SAF) play a controversial role in the discussion about the nature of the scrapie agent. In purification experiments SAF can be detected in brains of infected animals but not in spleen samples with similar titers of infectivity. Thus, SAF are not a constituent of the scrapie virus.

摘要

相似文献

1
The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent.
Arch Virol. 1986;91(3-4):383-6. doi: 10.1007/BF01314297.
2
Scrapie-infected spleens: analysis of infectivity, scrapie-associated fibrils, and protease-resistant proteins.瘙痒病感染的脾脏：传染性、瘙痒病相关纤维及抗蛋白酶蛋白分析
J Infect Dis. 1991 Jul;164(1):29-35. doi: 10.1093/infdis/164.1.29.
3
Detection of scrapie-associated fibrils (SAF) and SAF proteins from scrapie-affected sheep.从感染羊瘙痒病的绵羊中检测羊瘙痒病相关纤维（SAF）和SAF蛋白。
J Infect Dis. 1987 Jul;156(1):36-42. doi: 10.1093/infdis/156.1.36.
4
Pathogenesis of scrapie: study of the temporal development of clinical symptoms, of infectivity titres and scrapie-associated fibrils in brains of hamsters infected intraperitoneally.
J Gen Virol. 1986 Sep;67 ( Pt 9):2005-9. doi: 10.1099/0022-1317-67-9-2005.
5
Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations.在未纯化的组织制剂中使用抗瘙痒病相关纤维（SAF）抗体检测瘙痒病相关纤维（SAF）蛋白。
J Gen Virol. 1986 Apr;67 ( Pt 4):671-81. doi: 10.1099/0022-1317-67-4-671.
6
Molecular pathology of scrapie-associated fibril protein (PrP) in mouse brain affected by the ME7 strain of scrapie.
Eur J Biochem. 1988 Mar 1;172(2):271-7. doi: 10.1111/j.1432-1033.1988.tb13883.x.
7
Western blot detection of scrapie-associated fibril protein in tissues outside the central nervous system from preclinical scrapie-infected mice.
J Gen Virol. 1988 Apr;69 ( Pt 4):955-60. doi: 10.1099/0022-1317-69-4-955.
8
A rapid and efficient method to enrich SAF-protein from scrapie brains of hamsters.
Biosci Rep. 1984 Feb;4(2):165-70. doi: 10.1007/BF01120313.
9
Isolation and purification of scrapie-associated fibrils and prion protein from scrapie-infected hamster brain.从感染羊瘙痒病的仓鼠脑中分离和纯化羊瘙痒病相关纤维和朊病毒蛋白。
J Comp Pathol. 1989 Feb;100(2):177-85. doi: 10.1016/0021-9975(89)90128-x.
10
Scrapie: how much do we really understand?羊瘙痒症：我们究竟了解多少？
Neuropathol Appl Neurobiol. 1986 Mar-Apr;12(2):131-47. doi: 10.1111/j.1365-2990.1986.tb00046.x.

引用本文的文献

1
Scrapie: Report of an outbreak and brief review.羊瘙痒病：一次疫情报告及简要综述。
Can Vet J. 1989 Apr;30(4):321-7.
2
Improvement of PrPSc-detection in mouse spleen early at the preclinical stage of scrapie with collagenase-completed tissue homogenization and Sarkosyl-NaCl extraction of PrPSc.
Arch Virol. 1996;141(10):1863-74. doi: 10.1007/BF01718200.
3
Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology.关于羊瘙痒症及相关疾病的思考，并探讨病毒病因的可能性。

本文引用的文献

1
Abnormal fibrils from scrapie-infected brain.来自感染瘙痒病大脑的异常原纤维。
Acta Neuropathol. 1981;54(1):63-74. doi: 10.1007/BF00691333.
2
Novel proteinaceous infectious particles cause scrapie.新型蛋白质感染性颗粒可引发羊瘙痒病。
Science. 1982 Apr 9;216(4542):136-44. doi: 10.1126/science.6801762.
3
Scrapie infectivity, fibrils and low molecular weight protein.羊瘙痒病传染性、原纤维与低分子量蛋白质
Vet Res Commun. 1995;19(3):231-52. doi: 10.1007/BF01839302.
4
The molecular mechanisms of scrapie encephalopathy and relevance to human neurodegenerative disease.
Can J Vet Res. 1990 Jan;54(1):49-57.
5
Prion liposomes.朊病毒脂质体
Biochem J. 1990 Feb 15;266(1):1-14. doi: 10.1042/bj2660001.
6
Transmissible spongiform encephalopathies (TSE) virus-induced amyloidoses of the central nervous system (CNS).
Eur J Epidemiol. 1991 Sep;7(5):562-6. doi: 10.1007/BF00143140.
Nature. 1983;306(5942):476-8. doi: 10.1038/306476a0.
4
Purification and structural studies of a major scrapie prion protein.一种主要瘙痒病朊病毒蛋白的纯化及结构研究
Cell. 1984 Aug;38(1):127-34. doi: 10.1016/0092-8674(84)90533-6.
5
Scrapie prions aggregate to form amyloid-like birefringent rods.羊瘙痒病朊病毒聚集成淀粉样双折射杆状结构。
Cell. 1983 Dec;35(2 Pt 1):349-58. doi: 10.1016/0092-8674(83)90168-x.
6
Infection-specific particle from the unconventional slow virus diseases.来自非常规慢病毒疾病的感染特异性颗粒。
Science. 1984 Jul 27;225(4660):437-40. doi: 10.1126/science.6377496.
7
Antibodies to protein of scrapie-associated fibrils.
Lancet. 1984 Aug 11;2(8398):345. doi: 10.1016/s0140-6736(84)92708-9.
8
Pathogenesis of scrapie virus infection in the mouse.
J Infect Dis. 1967 Feb;117(1):15-22. doi: 10.1093/infdis/117.1.15.
9
Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain.
Nature. 1985;315(6017):331-3. doi: 10.1038/315331a0.
10
Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues.编码朊病毒蛋白前导肽的cDNA克隆的分离及同源基因在各种组织中的表达。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6377-81. doi: 10.1073/pnas.83.17.6377.