Brooks Stephen P J, Greene-Finestone Linda, Whiting Susan, Fioletov Vitali E, Laffey Patrick, Petronella Nicholas
Health Canada, Health Products and Food Branch, Bureau of Nutritional Sciences, 251 Sir Frederick Banting Driveway, Ottawa, ON, Canada K1A 0K9.
University of Saskatchewan, College of Pharmacy and Nutrition, Saskatoon, SK, Canada.
J AOAC Int. 2017 Sep 1;100(5):1345-1354. doi: 10.5740/jaoacint.17-0250. Epub 2017 Aug 4.
Vitamin D status was assessed in 19-79 year old whites (8351 participants of European ancestry) and non-whites (1840 participants encompassing all other ancestries) from cycles 1 to 3 (years 2007-2013) of the Canadian Health Measures Survey. Status was assessed using the U.S. Institute of Medicine (IOM) 25-hydroxyvitamin D [25(OH)D] cut point values of 30 and 40 nmol/L. Overall, median 25(OH)D concentrations were significantly higher in whites [58.9 (28.6, 100.1) nmol/L; 5th and 95th percentile] compared with non-whites [43.5 (19.0, 83.2); P < 0.001]. Values were higher in females [58.5 (27.5, 101.3) nmol/L] when compared with males [53.5 (24.2, 92.7) nmol/L] and increased with age. Non-whites were more likely to have 25(OH)D values below IOM established cut points for optimum bone health with 20.1 (16.0, 24.2) and 42.2% (36.8, 47.7) of non-whites having serum 25(OH)D concentrations <30 and <40 nmol/L, respectively. The corresponding values for whites were 5.9 (4.6, 7.2) and 16.1% (14.0, 18.3). Values were lower during the first quarter when compared with the third quarter. Supplement intake was an important factor in determining 25(OH)D levels, but it did not alone account for the difference in status. Equivalent increases in 25(OH)D levels were observed in whites and non-whites during the summer months, suggesting there was no functional difference in sun exposure response. It is apparent that a complex interaction of factors affect 25(OH)D values in free-living Canadians.
在加拿大健康措施调查的第1至3轮（2007 - 2013年）中，对19至79岁的白人（8351名欧洲血统参与者）和非白人（1840名涵盖所有其他血统的参与者）的维生素D状况进行了评估。使用美国医学研究所（IOM）设定的30和40 nmol/L的25 - 羟基维生素D [25(OH)D]切点值来评估状况。总体而言，白人的25(OH)D浓度中位数[58.9（28.6，100.1）nmol/L；第5和第95百分位数]显著高于非白人[43.5（19.0，83.2）；P < 0.001]。女性的值[58.5（27.5，101.3）nmol/L]高于男性[53.5（24.2，92.7）nmol/L]，并且随年龄增加。非白人更有可能具有低于IOM确定的最佳骨骼健康切点值的25(OH)D值，分别有20.1%（16.0，24.2）和42.2%（36.8，47.7）的非白人血清25(OH)D浓度<30和<40 nmol/L。白人的相应值为5.9%（4.6，7.2）和16.1%（14.0，18.3）。与第三季度相比，第一季度的值较低。补充剂摄入是决定25(OH)D水平的一个重要因素，但它并不能单独解释状况的差异。在夏季月份，白人和非白人的25(OH)D水平出现了同等程度的增加，这表明在阳光暴露反应方面没有功能差异。显然，多种因素的复杂相互作用影响着自由生活的加拿大人的25(OH)D值。
