Quang Dang Ngoc, So Tran Cong, Thanh Nguyen Thi Phuong, Hoa Le Thi Phuong, Dien Pham Huu, Luong Truong Minh, Tung Nguyen Quang, Long Le Duc, Dai Tran Duc, Tien Nguyen Quyet
a Faculty of Chemistry , Hanoi National University of Education , Hanoi , Vietnam.
b Faculty of Biology , Hanoi National University of Education , Hanoi , Vietnam.
Nat Prod Res. 2018 Apr;32(7):767-772. doi: 10.1080/14786419.2017.1359172. Epub 2017 Aug 4.
A new chalcone named as balanochalcone (1) together with eight known compounds, methyl caffeate (2), β-hydroxydihydrochalcone (3), methyl gallate (4), dimethyl-6,9,10-trihydroxybenzo[kl]xanthene-1,2-dicarboxylate (5), p-coumaric acid (6), quercetin (7), scopoletin (8) and pinoresinol (9) have been isolated from the ethyl acetate extract of Vietnamese Balanophora laxiflora Hemsl. Their structures were characterised by IR, UV, HR-ESI-MS, 1D and 2D NMR and CD spectroscopies. Compounds 2 and 5 showed moderate cytotoxicity against four cancer cell lines, KB (a human epidermal carcinoma), MCF7 (human breast carcinoma), SK-LU-1 (human lung carcinoma) and HepG2 (hepatocellular carcinoma). In addition, compounds 1 and 5 showed moderate antioxidant activity.
从越南松萝花（Balanophora laxiflora Hemsl.）的乙酸乙酯提取物中分离出一种名为巴拉诺查耳酮（1）的新查耳酮以及八种已知化合物，咖啡酸甲酯（2）、β-羟基二氢查耳酮（3）、没食子酸甲酯（4）、6,9,10-三羟基苯并[k,l]呫吨-1,2-二甲酸二甲酯（5）、对香豆酸（6）、槲皮素（7）、东莨菪素（8）和松脂醇（9）。通过红外光谱（IR）、紫外光谱（UV）、高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振（1D和2D NMR）以及圆二色光谱（CD）对它们的结构进行了表征。化合物2和5对四种癌细胞系，即KB（人表皮癌）、MCF7（人乳腺癌）、SK-LU-1（人肺癌）和HepG2（肝癌）显示出中等细胞毒性。此外，化合物1和5显示出中等抗氧化活性。
