Ferreira Fábio S, Pereira João M S, Reis Aldina, Sanches Mafalda, Duarte João V, Gomes Leonor, Moreno Carolina, Castelo-Branco Miguel
Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Laboratory of Biostatistics and Medical Informatics, Institute for Biomedical Imaging in Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Portugal.
Graefes Arch Clin Exp Ophthalmol. 2017 Nov;255(11):2113-2118. doi: 10.1007/s00417-017-3752-4. Epub 2017 Aug 4.
It is known that diabetic patients have changes in cortical morphometry as compared to controls, but it remains to be clarified whether the visual cortex is a disease target, even when diabetes complications such as retinopathy are absent. Therefore, we compared type 2 diabetes patients without diabetic retinopathy with control subjects using magnetic resonance imaging to assess visual cortical changes when retinal damage is not yet present.
We performed T1-weighted imaging in 24 type 2 diabetes patients without diabetic retinopathy and 27 age- and gender-matched controls to compare gray matter changes in the occipital cortex between groups using voxel based morphometry.
Patients without diabetic retinopathy showed reduced gray matter volume in the occipital lobe when compared with controls.
Reduced gray matter volume in the occipital cortex was found in diabetic patients without retinal damage. We conclude that cortical early visual processing regions may be affected in diabetic patients even before retinal damage occurs.
已知与对照组相比，糖尿病患者的皮质形态测量存在变化，但即便没有视网膜病变等糖尿病并发症，视觉皮质是否为疾病靶点仍有待阐明。因此，我们使用磁共振成像比较了无糖尿病视网膜病变的2型糖尿病患者与对照受试者，以评估视网膜损伤尚未出现时视觉皮质的变化。
我们对24例无糖尿病视网膜病变的2型糖尿病患者和27例年龄及性别匹配的对照者进行了T1加权成像，使用基于体素的形态测量法比较两组枕叶灰质的变化。
与对照组相比，无糖尿病视网膜病变的患者枕叶灰质体积减少。
在无视网膜损伤的糖尿病患者中发现枕叶皮质灰质体积减少。我们得出结论，即使在视网膜损伤发生之前，糖尿病患者的皮质早期视觉处理区域可能也会受到影响。
