光固化水溶性马来化壳聚糖/甲基丙烯酰化聚（乙烯醇）水凝胶作为潜在的组织工程支架。
Photopolymerized water-soluble maleilated chitosan/methacrylated poly (vinyl alcohol) hydrogels as potential tissue engineering scaffolds.
机构信息
College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, People's Republic of China; Key Laboratory of Green Processing and Functional Textiles of New Textile Materials, Ministry of Education, Wuhan Textile University, Wuhan 430073, People's Republic of China.
College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430073, People's Republic of China.
出版信息
Int J Biol Macromol. 2018 Jan;106:227-233. doi: 10.1016/j.ijbiomac.2017.08.002. Epub 2017 Aug 2.
Photocrosslinkable water-soluble maleilated chitosan and methacrylated poly (vinyl alcohol) were synthesized and therefore maleilated chitosan/methacrylated poly (vinyl alcohol) (MCS/MPVA) hydrogels were prepared under UV radiation. Series of properties of the hydrogels including rheological property, swelling behavior, morphology and mechanical test were investigated. The main results showed that the MCS/MPVA hydrogels had fast gel-forming rate (complete transformation to gel within 150s), improved compressive strength at 0.169±0.011MPa and rapid absorbent capacity. These behaviors could be tunable via the control of weight ratio of MCS to MPVA. The indirect cytotoxicity assessments demonstrated the photocrosslinked hydrogels was compatible to mouse fibroblasts (L929 cells), indicating their potential as tissue engineering scaffolds.
合成了光交联水溶性马来酸化壳聚糖和甲基丙烯酰化聚（乙烯醇），然后通过紫外光辐射制备了马来酸化壳聚糖/甲基丙烯酰化聚（乙烯醇）（MCS/MPVA）水凝胶。研究了水凝胶的一系列性能，包括流变性能、溶胀行为、形态和力学性能测试。主要结果表明，MCS/MPVA 水凝胶具有快速的成胶速率（在 150s 内完全转化为凝胶），提高了 0.169±0.011MPa 的压缩强度和快速的吸水性。这些性能可以通过控制 MCS 与 MPVA 的重量比来调节。间接细胞毒性评估表明，光交联水凝胶与小鼠成纤维细胞（L929 细胞）相容，表明其作为组织工程支架的潜力。
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