如促黑素细胞激素释放抑制因子-1/酪氨酰-促黑素细胞激素释放抑制因子-1所示的抗阿片系统的存在。
Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1.
作者信息
Galina Z H, Kastin A J
出版信息
Life Sci. 1986 Dec 8;39(23):2153-9. doi: 10.1016/0024-3205(86)90391-7.
PMID:2878336
Abstract
Evidence is presented that the small peptides MIF-1/Tyr-MIF-1 are part of an endogenous antiopiate system that may function to balance the opiate system. We review the biological activity, behavioral activity, and functional effects of this proposed opiate antagonist system. In addition, we suggest, based on antinociceptive mechanisms, that the individual components of the antiopiate system might function differently from naloxone.
摘要
有证据表明，小肽MIF-1/Tyr-MIF-1是内源性抗阿片系统的一部分，该系统可能起到平衡阿片系统的作用。我们综述了这个拟议的阿片拮抗剂系统的生物活性、行为活性和功能效应。此外，基于抗伤害感受机制，我们认为抗阿片系统的各个组分可能具有与纳洛酮不同的功能。
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