杏仁核点燃增加大鼠海马中脑啡肽样免疫反应性，但降低强啡肽 A 样免疫反应性。

Amygdaloid kindling increases enkephalin-like immunoreactivity but decreases dynorphin-A-like immunoreactivity in rat hippocampus.

作者信息

McGinty J F, Kanamatsu T, Obie J, Dyer R S, Mitchell C L, Hong J S

出版信息

Neurosci Lett. 1986 Oct 30;71(1):31-6. doi: 10.1016/0304-3940(86)90252-1.

Abstract

The effects of amygdaloid kindling on the regional levels and distribution of enkephalin-like and dynorphin-A (DN)-like immunoreactivity (LI) were examined. One day after completion of kindling, radioimmunoassay revealed a 71% decrease in DN1-8-LI and a 43% increase in [Met5]-enkephalin-LI in the hippocampus. Immunostaining revealed a depletion of DN1-17-LI in the hippocampal mossy fiber pathway and an increase in [Leu5]-enkephalin-LI in the temporoammonic pathway. Four weeks after completion of kindling, the levels and immunostaining intensity of dynorphin and enkephalin in the hippocampus had returned to control values.

摘要

研究了杏仁核点燃对脑啡肽样和强啡肽A（DN）样免疫反应性（LI）的区域水平和分布的影响。点燃完成一天后，放射免疫分析显示海马中DN1-8-LI降低71%，[Met5]-脑啡肽-LI增加43%。免疫染色显示海马苔藓纤维通路中DN1-17-LI减少，颞叶-海马通路中[Leu5]-脑啡肽-LI增加。点燃完成四周后，海马中强啡肽和脑啡肽的水平及免疫染色强度已恢复至对照值。