Liu Lei, Liu Li-Na, Wang Peng, Lv Tian-Tian, Fan Yin-Guang, Pan Hai-Feng
Department of Microbiology and Parasitology, Anhui Key Laboratory of Microbiology and Parasitology, Anhui Medical University, Hefei 230032 Anhui, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Acta Trop. 2017 Dec;176:162-167. doi: 10.1016/j.actatropica.2017.08.001. Epub 2017 Aug 4.
Clinical toxoplasmosis in AIDS/HIV patients is a great public health concern around the world. Untreated Toxoplasma gondii (T. gondii)-infections are often fatal in AIDS/HIV patients. This study aims to assess the seroprevalence and odds ratio (OR) of T. gondii in AIDS/HIV patients, as well as the potential influential factors. Studies published from December 1, 1983 to December 1, 2016 in English, which comparing the seroprevalence of T. gondii between AIDS/HIV patients and control group were searched in PubMed, EMBASE and The Cochrane Library databases. The non-weighted prevalence, pooled fixed-effect or random-effect model estimates of OR and its 95% confidence intervals (CI) were all calculated. Heterogeneity test was performed by the Q statistic and quantified using I, publication bias was evaluated using a funnel plot and Egger's linear regression test. A total of 4220 articles were obtained after searching databases, and 12 studies with 2101 AIDS/HIV patients and 5851 controls were incorporated in the meta-analysis. Meta-analysis revealed that, compared with the control group, the AIDS/HIV group had a higher seroprevalence of T. gondii (46.12% vs 36.56%) (OR=1.55, 95%CI: 1.19-2.04). Subgroup analyses showed that publication year, race, geographic locations and diagnostic methods are positive associated with the seroprevalence of T. gondii. Overall, our study suggests that AIDS/HIV patients have higher seroprevalence of T. gondii than those without.
艾滋病/艾滋病毒患者的临床弓形虫病是全球重大的公共卫生问题。未经治疗的弓形虫感染在艾滋病/艾滋病毒患者中往往是致命的。本研究旨在评估艾滋病/艾滋病毒患者中弓形虫的血清阳性率和比值比（OR），以及潜在的影响因素。检索了1983年12月1日至2016年12月1日发表的英文研究，这些研究比较了艾滋病/艾滋病毒患者与对照组之间弓形虫的血清阳性率，检索数据库为PubMed、EMBASE和Cochrane图书馆数据库。计算了非加权患病率、OR的合并固定效应或随机效应模型估计值及其95%置信区间（CI）。采用Q统计量进行异质性检验，并用I进行量化，采用漏斗图和Egger线性回归检验评估发表偏倚。检索数据库后共获得4220篇文章，12项研究纳入荟萃分析，其中包括2101例艾滋病/艾滋病毒患者和5851例对照。荟萃分析显示，与对照组相比，艾滋病/艾滋病毒组弓形虫血清阳性率更高（46.12%对36.56%）（OR=1.55，95%CI：1.19-2.04）。亚组分析表明，发表年份、种族、地理位置和诊断方法与弓形虫血清阳性率呈正相关。总体而言，我们的研究表明，艾滋病/艾滋病毒患者的弓形虫血清阳性率高于未感染艾滋病/艾滋病毒的患者。
