Zafar Muhammad, Najeeb Shariq, Khurshid Zohaib, Vazirzadeh Masoud, Zohaib Sana, Najeeb Bilal, Sefat Farshid
Department of Restorative Dentistry, College of Dentistry, Taibah University, Madina Munawwarah 41311, Saudi Arabia.
Department of Restorative Dental Sciences, Al Farabi Colleges, King Abdullah Road, Riyadh 11313, Saudi Arabia.
Materials (Basel). 2016 Jan 26;9(2):73. doi: 10.3390/ma9020073.
Electrospinning is a versatile technique that has gained popularity for various biomedical applications in recent years. Electrospinning is being used for fabricating nanofibers for various biomedical and dental applications such as tooth regeneration, wound healing and prevention of dental caries. Electrospun materials have the benefits of unique properties for instance, high surface area to volume ratio, enhanced cellular interactions, protein absorption to facilitate binding sites for cell receptors. Extensive research has been conducted to explore the potential of electrospun nanofibers for repair and regeneration of various dental and oral tissues including dental pulp, dentin, periodontal tissues, oral mucosa and skeletal tissues. However, there are a few limitations of electrospinning hindering the progress of these materials to practical or clinical applications. In terms of biomaterials aspects, the better understanding of controlled fabrication, properties and functioning of electrospun materials is required to overcome the limitations. More studies are definitely required to evaluate the biocompatibility of electrospun scaffolds. Furthermore, mechanical properties of such scaffolds should be enhanced so that they resist mechanical stresses during tissue regeneration applications. The objective of this article is to review the current progress of electrospun nanofibers for biomedical and dental applications. In addition, various aspects of electrospun materials in relation to potential dental applications have been discussed.
静电纺丝是一种用途广泛的技术，近年来在各种生物医学应用中颇受青睐。静电纺丝正被用于制造用于各种生物医学和牙科应用的纳米纤维，如牙齿再生、伤口愈合和预防龋齿。静电纺材料具有独特的性能优势，例如高比表面积、增强的细胞相互作用、蛋白质吸收以促进细胞受体的结合位点。已经进行了广泛的研究来探索静电纺纳米纤维在修复和再生各种牙齿和口腔组织（包括牙髓、牙本质、牙周组织、口腔黏膜和骨骼组织）方面的潜力。然而，静电纺丝存在一些局限性，阻碍了这些材料向实际或临床应用的发展。在生物材料方面，需要更好地理解静电纺材料的可控制造、性能和功能，以克服这些局限性。显然需要更多的研究来评估静电纺支架的生物相容性。此外，应增强此类支架的机械性能，以便它们在组织再生应用中抵抗机械应力。本文的目的是综述静电纺纳米纤维在生物医学和牙科应用方面的当前进展。此外，还讨论了静电纺材料与潜在牙科应用相关的各个方面。
