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通过表面接枝制备多功能Fe@Au核壳纳米颗粒作为磁热疗的潜在治疗方法

Preparation of Multifunctional Fe@Au Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia.

作者信息

Chung Ren-Jei, Shih Hui-Ting

机构信息

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan.

出版信息

Materials (Basel). 2014 Jan 24;7(2):653-661. doi: 10.3390/ma7020653.

DOI:10.3390/ma7020653
PMID:28788481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5453067/
Abstract

Iron core gold shell nanoparticles grafted with Methotrexate (MTX) and indocyanine green (ICG) were synthesized for the first time in this study, and preliminarily evaluated for their potential in magnetic hyperthermia treatment. The core-shell Fe@Au nanoparticles were prepared via the microemulsion process and then grafted with MTX and ICG using hydrolyzed poly(styrene-alt-maleic acid) (PSMA) to obtain core-shell Fe@Au-PSMA-ICG/MTX nanoparticles. MTX is an anti-cancer therapeutic, and ICG is a fluorescent dye. XRD, TEM, FTIR and UV-Vis spectrometry were performed to characterize the nanoparticles. The data indicated that the average size of the nanoparticles was 6.4 ± 09 nm and that the Au coating protected the Fe core from oxidation. MTX and ICG were successfully grafted onto the surface of the nanoparticles. Under exposure to high frequency induction waves, the superparamagnetic nanoparticles elevated the temperature of a solution in a few minutes, which suggested the potential for an application in magnetic hyperthermia treatment. The studies verified that the nanoparticles were biocompatible; nonetheless, the Fe@Au-PSMA-ICG/MTX nanoparticles killed cancer cells (Hep-G2) via the magnetic hyperthermia mechanism and the release of MTX.

摘要

本研究首次合成了接枝甲氨蝶呤（MTX）和吲哚菁绿（ICG）的铁芯金壳纳米颗粒，并对其在磁热疗中的潜力进行了初步评估。通过微乳液法制备核壳Fe@Au纳米颗粒，然后使用水解聚（苯乙烯-alt-马来酸）（PSMA）将MTX和ICG接枝到其上，以获得核壳Fe@Au-PSMA-ICG/MTX纳米颗粒。MTX是一种抗癌治疗药物，ICG是一种荧光染料。采用XRD、TEM、FTIR和UV-Vis光谱对纳米颗粒进行表征。数据表明，纳米颗粒的平均尺寸为6.4±0.9nm，金涂层保护铁核不被氧化。MTX和ICG成功接枝到纳米颗粒表面。在高频感应波照射下，超顺磁性纳米颗粒在几分钟内使溶液温度升高，这表明其在磁热疗中的应用潜力。研究证实纳米颗粒具有生物相容性；尽管如此，Fe@Au-PSMA-ICG/MTX纳米颗粒通过磁热疗机制和MTX的释放杀死癌细胞（Hep-G2）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/b99fd6ee8c41/materials-07-00653f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/1135483474de/materials-07-00653f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/fb15efd06cd4/materials-07-00653f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/78d7959331c8/materials-07-00653f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/e6f5c9d64775/materials-07-00653f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/de8df12a01d8/materials-07-00653f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/057150cfd6c1/materials-07-00653f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/b99fd6ee8c41/materials-07-00653f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/1135483474de/materials-07-00653f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/fb15efd06cd4/materials-07-00653f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/78d7959331c8/materials-07-00653f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/e6f5c9d64775/materials-07-00653f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/de8df12a01d8/materials-07-00653f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/057150cfd6c1/materials-07-00653f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/5453067/b99fd6ee8c41/materials-07-00653f7.jpg

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