Joshi Utsav, Subedi Roshan, Poudel Prakash, Ghimire Prajwol Ram, Panta Sagar, Sigdel Mahesh Raj
Department of Internal Medicine, Tribhuvan University, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Int J Nephrol Renovasc Dis. 2017 Jul 19;10:195-203. doi: 10.2147/IJNRD.S136522. eCollection 2017.
Assessment of quality of life (QOL) of patients with end-stage renal disease has become increasingly important, both in order to evaluate the influence of the disease on patients and the type of renal replacement therapy they require. Therefore, in this study, we aimed to assess QOL in patients undergoing hemodialysis and evaluated the effects of various sociodemographic factors affecting QOL of such patients in Nepal.
A cross-sectional study was conducted among 150 patients with chronic kidney disease undergoing hemodialysis at two major centers in Nepal. Demographic data including age, sex, ethnicity, educational status, marital status, employment, income, duration of illness, and duration on hemodialysis were collected. QOL was assessed using the World Health Organization Quality of life (WHOQOL-BREF) questionnaire. Four domains (physical, psychological, social, and environmental) and two items (overall perception of QOL and health) of the WHOQOL-BREF were the primary end points of this study. Bivariate relationship between sociodemographic factors and QOL scores were analyzed using independent samples -test and one-way analysis of variance. Multiple linear regression analysis was performed to determine independent predictors of QOL.
Following QOL scores were recorded: environmental domain (53.17±15.59), psychological domain (51.23±18.61), social domain (49.86±21.64), and physical domain (45.93±16.90). Older age was associated with a better QOL score in the social domain (=0.005), and employed patients scored better in the environmental domain (=0.019). Unemployed patients and those of the Terai/Madhesi ethnic group had significantly low scores in overall perception of health (<0.05) as compared to other groups. Low income status and increased duration on hemodialysis were found to be the only independent negative predictors of QOL in patients with hemodialysis (<0.05).
Patients with chronic kidney disease on dialysis had overall low QOL scores in all four domains. Age, ethnicity, employment status, income, and duration on hemodialysis affected one or more domains of QOL in such patients. Low income status and increased duration on hemodialysis were the only independent negative predictors of QOL of patients on maintenance hemodialysis.
评估终末期肾病患者的生活质量（QOL）变得越来越重要，这既是为了评估疾病对患者的影响，也是为了评估他们所需的肾脏替代治疗类型。因此，在本研究中，我们旨在评估接受血液透析患者的生活质量，并评估尼泊尔影响此类患者生活质量的各种社会人口学因素的作用。
在尼泊尔两个主要中心对接受血液透析的150例慢性肾病患者进行了一项横断面研究。收集了包括年龄、性别、种族、教育状况、婚姻状况、就业、收入、病程和血液透析时间等人口统计学数据。使用世界卫生组织生活质量（WHOQOL-BREF）问卷评估生活质量。WHOQOL-BREF的四个领域（身体、心理、社会和环境）以及两个项目（生活质量和健康的总体感知）是本研究的主要终点。使用独立样本t检验和单因素方差分析分析社会人口学因素与生活质量得分之间的双变量关系。进行多元线性回归分析以确定生活质量的独立预测因素。
记录到以下生活质量得分：环境领域（53.17±15.59）、心理领域（51.23±18.61）、社会领域（49.86±21.64）和身体领域（45.93±16.90）。年龄较大与社会领域更好的生活质量得分相关（P = 0.005），就业患者在环境领域得分更高（P = 0.019）。与其他组相比，失业患者和特莱/马德西族患者在健康总体感知方面得分显著较低（P<0.05）。低收入状态和血液透析时间延长被发现是血液透析患者生活质量的唯一独立负面预测因素（P<0.0
