Department of Health Services, Ministry of Health and Population, Kathmandu, Nepal.
Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
BMC Nephrol. 2020 Oct 12;21(1):433. doi: 10.1186/s12882-020-02085-0.
Very less is known about health-related quality of life (HRQOL) among patients with kidney diseases in Nepal. This study examined HRQOL among haemodialysis and kidney transplant recipients in Nepal.
The Nepali version of World Health Organization Quality of Life Instruments -(WHOQOL-BREF) questionnaire was administered using face to face interviews among end stage renal disease (ESRD) patients, from two large national referral centers in Nepal. The differences in socio-demographic characteristics among ESRD patients were examined using the Chi-square test. The group differences in quality of life (QOL) were examined using the Mann-Whitney U test and Kruskal-Wallis tests.
Of the 161 participants, 92 (57.1%) were renal transplant recipients and 69 (42.9%) patients were on maintenance haemodialysis. Hypertension (70.9%) was the most common co-morbidity among ESRD patients. Haemodialysis patients scored significantly lower than the transplant recipients in all four domains as well as in overall perception of quality of life and general health. Ethnicity (p = 0.020), socio-economic status (p < 0.001), educational status (p < 0.001) and employment status (p = 0.009) were significantly associated with the overall QOL in ESRD patients. Across patient groups, educational status (p = 0.012) was positively associated with QOL in dialysis patients, while urban residence (p = 0.023), higher socio-economic status (p < 0.001), higher educational status (p = 0.004) and diabetes status (p = 0.010) were significantly associated with better QOL in transplant recipients.
The overall QOL of the renal transplant recipients was higher than that of the patients on maintenance haemodialysis; this was true in all four domains of the WHOQOL-BREF. ESRD patients with low HRQOL could benefit from targeted risk modification intervention.
尼泊尔的肾病患者健康相关生活质量（HRQOL）知之甚少。本研究调查了尼泊尔血液透析和肾移植受者的 HRQOL。
使用面对面访谈，在尼泊尔的两个大型国家转诊中心，向终末期肾病（ESRD）患者发放世界卫生组织生活质量量表（WHOQOL-BREF）尼泊尔语版本问卷。使用卡方检验比较 ESRD 患者的社会人口统计学特征差异。使用 Mann-Whitney U 检验和 Kruskal-Wallis 检验比较生活质量（QOL）的组间差异。
在 161 名参与者中，92 名（57.1%）为肾移植受者，69 名（42.9%）患者接受维持性血液透析。高血压（70.9%）是 ESRD 患者最常见的合并症。血液透析患者在所有四个领域以及对生活质量和总体健康的总体感知方面的评分均明显低于移植受者。种族（p=0.020）、社会经济地位（p<0.001）、教育程度（p<0.001）和就业状况（p=0.009）与 ESRD 患者的总体 QOL 显著相关。在患者群体中，教育程度（p=0.012）与透析患者的 QOL 呈正相关，而城市居住（p=0.023）、较高的社会经济地位（p<0.001）、较高的教育程度（p=0.004）和糖尿病状态（p=0.010）与移植受者的 QOL 显著相关。
肾移植受者的总体 QOL 高于维持性血液透析患者；这在 WHOQOL-BREF 的所有四个领域都是如此。生活质量低的 ESRD 患者可能受益于有针对性的风险修正干预。
