将微组织整合到用于再生纳米医学的纳米纤维支架中。

Integrating Microtissues in Nanofiber Scaffolds for Regenerative Nanomedicine.

作者信息

Keller Laetitia, Wagner Quentin, Offner Damien, Eap Sandy, Musset Anne-Marie, Arruebo Manuel, Kelm Jens M, Schwinté Pascale, Benkirane-Jessel Nadia

机构信息

INSERM (French National Institute of Health and Medical Research), "Osteoarticular and Dental Regenerative Nanomedicine" laboratory, UMR 1109, Faculté de Médecine, Strasbourg Cedex F-67085, France.

Université de Strasbourg, Faculté de Chirurgie Dentaire, 1 place de l'Hôpital, Strasbourg F-67000, France.

出版信息

Materials (Basel). 2015 Oct 9;8(10):6863-6867. doi: 10.3390/ma8105342.

DOI:10.3390/ma8105342

PMID:28793604

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5455384/

Abstract

A new generation of biomaterials focus on smart materials incorporating cells. Here, we describe a novel generation of synthetic nanofibrous implant functionalized with living microtissues for regenerative nanomedicine. The strategy designed here enhances the effectiveness of therapeutic implants compared to current approaches used in the clinic today based on single cells added to the implant.

摘要

新一代生物材料聚焦于包含细胞的智能材料。在此，我们描述了一种新型的合成纳米纤维植入物，其用活的微组织进行功能化，用于再生纳米医学。与当今临床使用的基于向植入物中添加单个细胞的现有方法相比，此处设计的策略提高了治疗性植入物的有效性。