Al-Osail Aisha M, Al-Wazzah Marwan J
Imam abdulrahman Alfaisal University (University of Dammam previously), Prince Saud bin Fahd Street, P.O. Box 3669, Khobar, 31952 Saudi Arabia.
Multidiscip Respir Med. 2017 Aug 7;12:20. doi: 10.1186/s40248-017-0101-8. eCollection 2017.
Corona viruses cause common cold, and infections caused by corona viruses are generally self-resolving. During the last 4 years, corona viruses have become the most important viruses worldwide because of the occurrence of several recent deaths caused by corona viruses in Saudi Arabia. Spread of the infection occurred worldwide; however, most cases of mortality have occurred in the Middle East. Owing to the predominance of outbreaks in the Middle Eastern countries, the virus was renamed a Middle East respiratory syndrome corona virus (MERS-CoV) by the Corona virus Study Group. The Center for Diseases Control and Prevention and World Health Organization maintain a website that is updated frequently with new cases of MERS-CoV infection. In this review, we describe the history and epidemiology of this novel virus. Studies of the genetics and molecular mechanisms of this virus are expected to facilitate the development of vaccines in the future.
冠状病毒可引起普通感冒，由冠状病毒引起的感染通常可自行痊愈。在过去4年里，由于沙特阿拉伯最近出现了几例由冠状病毒导致的死亡病例，冠状病毒已成为全球最重要的病毒。感染在全球范围内传播；然而，大多数死亡病例发生在中东地区。由于中东国家疫情的 predominance（此处原文有误，应是predominance，意为“主导地位”），该病毒被冠状病毒研究小组重新命名为中东呼吸综合征冠状病毒（MERS-CoV）。疾病控制与预防中心和世界卫生组织维护着一个网站，该网站会随着MERS-CoV感染新病例的出现而频繁更新。在这篇综述中，我们描述了这种新型病毒的历史和流行病学情况。对这种病毒的遗传学和分子机制的研究有望在未来推动疫苗的研发。
