Department of Dermatology, University Hospital Zealand, Roskilde, Denmark.
Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark.
J Eur Acad Dermatol Venereol. 2018 Feb;32(2):313-317. doi: 10.1111/jdv.14511. Epub 2017 Oct 11.
In recent years, Hidradenitis suppurativa has received increased attention but still lack well-defined, robust patient-reported outcome measures. Such measures are likely to be influenced by contextual factors. We, therefore, aim to describe the association of biological and other factors with HS patient's self-evaluated health as reflected by the EQ5D VAS score.
This cross-sectional study measured basic information, Dermatology Life Quality Index, Major Depression Inventory and Euro-QoL-5D. Information obtained through questionnaires was used to create a model showing the relation between biological factors, questionnaire results and self-evaluated health using the stepwise method for linear regression. Patients with HS (n = 805) registered at our department were invited to participate. A total of 503 (62.5%) patients replied to this survey. There was no difference in basic demographics between responders and non-responders.
Possible predictors for this study were DLQI, MDI, BMI, smoking, gender. A final model for correlation with self-evaluated health was obtained. Significant predictors for the model were DLQI (P < 0.05), BMI points above 25 and active smoking (both: P < 0.01) and MDI (P < 0.001).
As this is a cross-sectional study, it reveals several clinically relevant correlations. Smoking appears to correlate with the highest change in VAS score, but an MDI of 10 (lower than study average) or a BMI of 40 influences the results more. This study provides an assessment of how much BMI and smoking, in relation to other factors, correlate to the self-evaluated health state of patients with HS. These may, therefore, be relevant contextual factors to the construction and interpretation of specific patient-reported outcome measures. To improve QoL, we advocate smoking cessation and weight loss, and advice active screening for depression as over 10% of our patients qualify for a depressive diagnosis according to ICD-10.
近年来，化脓性汗腺炎受到了越来越多的关注，但仍缺乏明确的、稳健的患者报告结局测量。这些措施可能受到环境因素的影响。因此，我们旨在描述生物因素和其他因素与 HS 患者自我评估健康状况的关系，这种关系由 EQ5D VAS 评分反映。
本横断面研究测量了基本信息、皮肤病生活质量指数、重度抑郁量表和 Euro-QoL-5D。通过问卷调查获得的信息用于创建一个模型，该模型使用逐步线性回归方法显示生物因素、问卷结果与自我评估健康之间的关系。邀请我院皮肤科登记的化脓性汗腺炎患者参与。共有 503 名（62.5%）患者回复了这份调查。应答者和未应答者的基本人口统计学特征无差异。
本研究的可能预测因子为 DLQI、MDI、BMI、吸烟、性别。获得了与自我评估健康相关的最终模型。对模型有显著预测作用的是 DLQI（P<0.05）、BMI 高于 25 点和主动吸烟（均 P<0.01）和 MDI（P<0.001）。
由于这是一项横断面研究，它揭示了一些具有临床相关性的相关性。吸烟似乎与 VAS 评分的变化最相关，但 MDI 为 10（低于研究平均值）或 BMI 为 40 对结果的影响更大。本研究评估了 BMI 和吸烟与其他因素相比，与化脓性汗腺炎患者自我评估健康状况的相关性。因此，这些可能是构建和解释特定患者报告结局测量的相关环境因素。为了提高生活质量，我们提倡戒烟和减肥，并建议积极筛查抑郁，因为根据 ICD-10，我们超过 10%的患者符合抑郁诊断标准。
