Department of Health Economics, Corvinus University of Budapest, Fővám tér 8, H-1093, Budapest, Hungary.
Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, Üllői út 26, H-1085, Budapest, Hungary.
Qual Life Res. 2021 May;30(5):1477-1490. doi: 10.1007/s11136-020-02732-x. Epub 2021 Feb 3.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that affects up to 1% of the population in Europe. The EQ-5D is the most commonly used generic instrument for measuring health-related quality of life among HS patients. This study aims to compare the measurement properties of the two adult versions of EQ-5D (EQ-5D-3L and EQ-5D-5L) in patients with HS.
We recruited 200 consecutive patients with HS (mean age 37 years, 38% severe or very severe HS) to participate in a multicentre cross-sectional survey. Patients completed the EQ-5D-3L, EQ-5D-5L, Dermatology Life Quality Index (DLQI) and Skindex-16 questionnaires.
More than twice as many different health state profiles occurred in the EQ-5D-5L compared to the EQ-5D-3L (101 vs. 43). A significant reduction in ceiling effect was found for the mobility, self-care and usual activities dimensions. A good agreement was established between the EQ-5D-3L and EQ-5D-5L with an intraclass correlation coefficient of 0.872 (95% CI 0.830-0.903; p < 0.001) that was confirmed by a Bland-Altman plot. EQ-5D-5L improved both the absolute and relative informativity in all dimensions except for anxiety/depression. EQ-5D-3L and EQ-5D-5L demonstrated similar convergent validity with DLQI and Skindex-16. EQ-5D-5L was able to better discriminate between known groups of patients based on the number of comorbidities and disease severity (HS-Physician's Global Assessment).
In patients with HS, the EQ-5D-5L outperformed the EQ-5D-3L in feasibility, ceiling effects, informativity and known-groups validity for many important clinical characteristics. We recommend using the EQ-5D-5L in HS patients across various settings, including clinical care, research and economic evaluations.
化脓性汗腺炎（HS）是一种影响欧洲人群中高达 1%的慢性炎症性皮肤病。EQ-5D 是用于衡量 HS 患者健康相关生活质量的最常用的通用工具。本研究旨在比较 EQ-5D 的两种成人版本（EQ-5D-3L 和 EQ-5D-5L）在 HS 患者中的测量特性。
我们招募了 200 名连续的 HS 患者（平均年龄 37 岁，38%为严重或非常严重的 HS）参加多中心横断面调查。患者完成了 EQ-5D-3L、EQ-5D-5L、皮肤病生活质量指数（DLQI）和 Skindex-16 问卷。
EQ-5D-5L 比 EQ-5D-3L 出现的健康状态谱多了两倍以上（101 比 43）。在移动性、自我护理和日常活动维度上发现显著降低了天花板效应。EQ-5D-3L 和 EQ-5D-5L 之间建立了良好的一致性，组内相关系数为 0.872（95%置信区间 0.830-0.903；p<0.001），这通过 Bland-Altman 图得到了证实。EQ-5D-5L 在除焦虑/抑郁外的所有维度上都提高了绝对和相对信息量。EQ-5D-3L 和 EQ-5D-5L 与 DLQI 和 Skindex-16 均显示出相似的收敛效度。EQ-5D-5L 能够根据共病数量和疾病严重程度（HS-医生总体评估）更好地区分已知患者组。
在 HS 患者中，EQ-5D-5L 在可行性、天花板效应、信息量和已知组有效性方面优于 EQ-5D-3L，可用于衡量 HS 患者的许多重要临床特征。我们建议在各种情况下（包括临床护理、研究和经济评估）在 HS 患者中使用 EQ-5D-5L。
