Singh Lavleen, Singh Amitabh, Agarwal Mitali, Mishra Sataroopa
Lavleen Singh, Amitabh Singh, Mitali Agarwal, Sataroopa Mishra, Department of Pathology, Chacha Nehru Bal Chikitsalaya, Geeta Colony 110031, New Delhi, India.
World J Clin Cases. 2017 Jul 16;5(7):303-306. doi: 10.12998/wjcc.v5.i7.303.
Dengue virus infection continues to be major public health problem in large part of world. The epidemiology of dengue viral infection is becoming increasingly complex and has substantially changed over almost past six decades not only in terms of prevalent strains and geographical locations but also in terms of disease severity and atypical presentations. Though liver is the most common organ affected but is generally asymptomatic. We present a case of infant with severe dengue who died of fulminant hepatic failure and showed pan lobular necrosis on post mortem liver biopsy. The case is being presented to highlight life threatening complication of dengue in young children, and dengue viral infection as a cause of acute liver failure in endemic areas. Thus dengue fever should also be considered as one of the differential diagnosis in children presenting with fever and fulminant hepatic failure in endemic regions.
登革病毒感染在世界大部分地区仍然是一个主要的公共卫生问题。登革病毒感染的流行病学正变得越来越复杂，在过去近六十年里发生了很大变化，不仅在流行毒株和地理位置方面，而且在疾病严重程度和非典型表现方面。虽然肝脏是最常受影响的器官，但通常没有症状。我们报告一例严重登革热婴儿病例，该婴儿死于暴发性肝衰竭，尸检肝脏活检显示全小叶坏死。报告该病例是为了强调幼儿登革热的危及生命的并发症，以及登革病毒感染作为流行地区急性肝衰竭的一个原因。因此，在流行地区出现发热和暴发性肝衰竭的儿童中，登革热也应被视为鉴别诊断之一。
