School of Aerospace Engineering and Applied Mechanics, Tongji University, Shanghai, 200092, P. R. China.
School of Life Sciences, Fudan University, Shanghai, 200433, P. R. China.
Sci Rep. 2017 Aug 11;7(1):7990. doi: 10.1038/s41598-017-08565-y.
Dynamic reconfiguration of the human brain is characterized by the nature of complexity. The purpose of this study was to measure such complexity and also analyze its association with age. We modeled the dynamic reconfiguration process by dynamic functional connectivity, which was established by resting-state functional magnetic resonance imaging (fMRI) data, and we measured complexity within the dynamic functional connectivity by sample entropy (SampEn). A brainwide map of SampEn in healthy subjects shows larger values in the caudate, the olfactory gyrus, the amygdala, and the hippocampus, and lower values in primary sensorimotor and visual areas. Association analysis in healthy subjects indicated that SampEn of the amygdala-cortical connectivity decreases with advancing age. Such age-related loss of SampEn, however, disappears in patients with schizophrenia. These findings suggest that SampEn of the dynamic functional connectivity is a promising indicator of normal aging.
人脑的动态重组以复杂性为特征。本研究的目的是测量这种复杂性，并分析其与年龄的关系。我们通过动态功能连接来模拟动态重组过程，该连接是通过静息状态功能磁共振成像（fMRI）数据建立的，我们通过样本熵（SampEn）来测量动态功能连接中的复杂性。在健康受试者的大脑中，SampEn 的全脑图谱显示尾状核、嗅球、杏仁核和海马体的数值较大，而初级感觉运动和视觉区域的数值较低。在健康受试者中的关联分析表明，杏仁核-皮质连接的 SampEn 随年龄增长而降低。然而，在精神分裂症患者中，这种与年龄相关的 SampEn 损失消失了。这些发现表明，动态功能连接的 SampEn 是正常衰老的一个有前途的指标。
