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凝血混合试验的性能与解读

Performance and Interpretation of Mixing Tests in Coagulation.

作者信息

Kershaw Geoffrey

机构信息

Institute of Haematology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia.

出版信息

Methods Mol Biol. 2017;1646:85-90. doi: 10.1007/978-1-4939-7196-1_6.

DOI:10.1007/978-1-4939-7196-1_6
PMID:28804820
Abstract

Mixing tests in coagulation studies allow the laboratory to correctly differentiate factor deficiency from inhibitors as the cause of a prolonged clotting time. This is important in terms of subsequent laboratory follow-up and clinical patient management. In this chapter, a suggested method of performing mixing tests is given, with procedures applying two different formulas for interpretation, the percent correction and the index of circulating anticoagulant.

摘要

凝血研究中的混合试验可使实验室正确区分凝血因子缺乏与抑制剂,以确定凝血时间延长的原因。这对于后续的实验室随访及临床患者管理而言至关重要。本章给出了一种进行混合试验的建议方法,并介绍了应用两种不同公式进行解读的程序,即校正百分比和循环抗凝剂指数。

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Performance and Interpretation of Mixing Tests in Coagulation.凝血混合试验的性能与解读
Methods Mol Biol. 2017;1646:85-90. doi: 10.1007/978-1-4939-7196-1_6.
2
Mixing tests: diagnostic aides in the investigation of prolonged prothrombin times and activated partial thromboplastin times.混合试验:在延长的凝血酶原时间和活化部分凝血活酶时间研究中的诊断辅助手段。
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Evaluation of prothrombin time and activated partial thromboplastin time mixing studies using an estimated factor correction method.使用估计因子校正方法评估凝血酶原时间和活化部分凝血活酶时间混合试验。
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Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants.活化部分凝血活酶时间(APTT)检测:确定试剂对因子缺乏、肝素和狼疮抗凝物的敏感性
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Prothrombin time and partial thromboplastin time assay considerations.凝血酶原时间和部分凝血活酶时间测定的注意事项。
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Point-of-care PT and aPTT in patients with suspected deficiencies of coagulation factors.疑似凝血因子缺乏患者的即时检验凝血酶原时间(PT)和活化部分凝血活酶时间(aPTT)
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Applying a direct aPTT ratio (PlatelinLS/ActinFS) permits to identify rapidly and reliably a bleeding-related factor deficiency or a lupus anticoagulant sequential to an isolated prolongation of aPTT in paediatric pre-operative screening.应用直接活化部分凝血活酶时间比值(PlatelinLS/ActinFS)能够在儿科术前筛查中,针对活化部分凝血活酶时间单独延长的情况,快速且可靠地识别出与出血相关的因子缺乏或狼疮抗凝物。
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[Test for detection of activated partial thromboplastin time using ellagic acid].[使用鞣花酸检测活化部分凝血活酶时间的试验]
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