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多发性硬化症与精神分裂症。

Multiple Sclerosis and Schizophrenia.

作者信息

Arneth Borros M

机构信息

Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg (UKGM), Justus Liebig University Giessen, Feulgenstr. 12, 35392 Giessen, Germany.

出版信息

Int J Mol Sci. 2017 Aug 12;18(8):1760. doi: 10.3390/ijms18081760.

Abstract

The psychiatric and neurological aspects of health may present methodological challenges in the diagnosis and treatment of disease. This is especially true for patients whose symptoms indicate the coexistence of multiple sclerosis (MS) and schizophrenia (SCZ). These cases raise critical questions regarding the relationship between the mind and the brain. Studies have noted that patients with MS have an increased risk of developing SCZ or bipolar disorder (BD). It is suggested here that MS and a subgroup of SCZ have similar etiologies. Factors such as gender, ethnicity, geography and season also have an influence on the occurrence of MS and SCZ. This paper aims to examine the differences and similarities between SCZ and MS. For this purpose, scientific papers examining various factors associated with these disorders were reviewed, and similarities and differences in genetic, immunological, seasonal, geographical, and gender-related risk factors and limited similarities in ethnic factors between the two diseases were identified. The findings suggest that subgroups of these two diseases may belong to the same class of disorders.

摘要

健康的精神和神经方面在疾病的诊断和治疗中可能会带来方法学上的挑战。对于那些症状表明患有多发性硬化症(MS)和精神分裂症(SCZ)的患者来说尤其如此。这些病例引发了关于心智与大脑之间关系的关键问题。研究指出,患有MS的患者患SCZ或双相情感障碍(BD)的风险增加。本文认为MS和SCZ的一个亚组具有相似的病因。性别、种族、地理位置和季节等因素也会对MS和SCZ的发生产生影响。本文旨在研究SCZ和MS之间的异同。为此,回顾了研究与这些疾病相关的各种因素的科学论文,并确定了两种疾病在遗传、免疫、季节、地理和性别相关风险因素方面的异同,以及在种族因素方面有限的相似之处。研究结果表明,这两种疾病的亚组可能属于同一类疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feb6/5578149/4acebc2cc60a/ijms-18-01760-g001.jpg

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