Huo Junfeng, Dong Aiguo, Wang Yonghui, Lee Shaochin, Ma Cungen, Wang Lan
School of Life Science, Shanxi University, Taiyuan, Shanxi Province, China; 2011 Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi Province, China.
2011 Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi Province, China.
Chemosphere. 2017 Nov;186:459-465. doi: 10.1016/j.chemosphere.2017.08.029. Epub 2017 Aug 7.
The study investigated the histopathological and ultrastructural lesions of liver of freshwater turtle Chinemys reevesii exposed to Cadmium (Cd). The animals were exposed to 0 mg kg (0.85% normal saline (NS)), 7.5 mg kg, 15 mg kg, 30 mg kg Cd chloride separately by intraperitoneal injection. Liver samples were collected for examination of lesions under light and electronic microscopes. Results showed that liver tissues from Cd -treated animals presented various degrees of histopathological lesions. Liver cells showed swollen, degeneration and necrosis with dose-dependent manner. Under electronic microscope, nucleus, mitochondria and rough endoplasmic reticulum presented various degrees of lesions with dose-dependent manner. In conclusion, Cd has significant toxicity on liver tissue of the freshwater turtle, which occurs in a dose-dependent manner.
该研究调查了暴露于镉（Cd）的中华鳖肝脏的组织病理学和超微结构损伤。通过腹腔注射将动物分别暴露于0毫克/千克（0.85%生理盐水（NS））、7.5毫克/千克、15毫克/千克、30毫克/千克的氯化镉中。收集肝脏样本，在光学显微镜和电子显微镜下检查损伤情况。结果表明，镉处理动物的肝脏组织出现了不同程度的组织病理学损伤。肝细胞呈现肿胀、变性和坏死，且具有剂量依赖性。在电子显微镜下，细胞核、线粒体和粗面内质网呈现不同程度的损伤，也具有剂量依赖性。总之，镉对中华鳖肝脏组织具有显著毒性，且呈剂量依赖性。
