School of Life Science, Shanxi University, Taiyuan, Shanxi Province, China.
The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi Province, China.
Environ Sci Pollut Res Int. 2018 Mar;25(8):8027-8034. doi: 10.1007/s11356-017-1139-z. Epub 2018 Jan 5.
Cadmium (Cd) has been recently found in high concentrations in the aquatic environment. This study was designed to examine the effects of Cd on the oxidative stress activities in plasma of freshwater turtle Chinemys reevesii. Experimental turtles were exposed to Cd at the concentration of 15 mg/kg by intraperitoneal injection, and redox status was investigated. Compared to the controls, superoxide dismutase (SOD) and catalase activities in plasma of the treated animals significantly decreased in week 1, week 2, and week 4. However, SOD activities gradually increased from week 4 to week 8. The treated animals had higher content of MDA and lower content of GSH in plasma over the observation period. In conclusion, our results showed that Cd decreased the antioxidant capacity and increased the level of oxidative damage product in plasma, which suggest that Cd causes oxidative stress and damage in the animal under the experimental conditions.
镉（Cd）最近在水环境中被发现浓度很高。本研究旨在探讨镉对淡水龟中华鳖（Chinemys reevesii）血浆氧化应激活性的影响。实验龟通过腹腔注射暴露于浓度为 15mg/kg 的 Cd，研究了氧化还原状态。与对照组相比，处理组动物血浆中超氧化物歧化酶（SOD）和过氧化氢酶活性在第 1、2 和 4 周显著降低，但 SOD 活性在第 4 周到第 8 周逐渐增加。处理组动物在整个观察期间血浆中的 MDA 含量较高，GSH 含量较低。总之，我们的结果表明，Cd 降低了抗氧化能力并增加了血浆中氧化损伤产物的水平，这表明在实验条件下 Cd 会导致动物的氧化应激和损伤。
