Dong Aiguo, Dong Huidong, He Hui, Dong Ailing, Yan Juanjuan, Huo Junfeng
Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China.
Bureau of Agriculture and Rural Affairs of Qianan, Tangshan, Hebei Province, China.
Biol Trace Elem Res. 2023 Jun;201(6):3000-3005. doi: 10.1007/s12011-022-03397-y. Epub 2022 Aug 19.
This research studied the effects of cadmium on kidney function of the freshwater turtles Mauremys reevesii. Turtles were injected intraperitoneally with 0, 7.5, 15, and 30 mg kg cadmium separately for once. The samples were gathered to check the kidney index, the contents of TP in kidney tissue, and the levels of CRE and BUN in the plasma of the turtles. Results showed that the concentration of TP was overall decreased with the extension of cadmium exposure time and the increasing of the exposure dose of cadmium. The CRE content in the plasma of each treatment group increased with the prolongation of exposure time in a dose-dependent, and the BUN levels of all poisoned groups showed a trend of increasing. The kidney index of treated turtles increased. In summary, cadmium could induce the increase of turtle kidney index, the content of CRE and BUN in plasma, and the decrease of TP content in the kidney.
本研究探讨了镉对淡水龟中华草龟肾功能的影响。分别对龟一次性腹腔注射0、7.5、15和30毫克/千克镉。采集样本检测龟的肾脏指数、肾组织中总蛋白(TP)含量以及血浆中肌酐(CRE)和尿素氮(BUN)水平。结果表明,随着镉暴露时间的延长和镉暴露剂量的增加,TP浓度总体下降。各处理组血浆中CRE含量随暴露时间延长呈剂量依赖性增加,所有中毒组的BUN水平均呈上升趋势。经处理的龟的肾脏指数增加。综上所述,镉可导致龟肾脏指数升高、血浆中CRE和BUN含量增加以及肾脏中TP含量降低。