Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.
J Am Chem Soc. 2017 Aug 30;139(34):11686-11689. doi: 10.1021/jacs.7b05901. Epub 2017 Aug 17.
Methylenecyclopropanes are important synthetic intermediates that possess strain energies exceeding those of saturated cyclopropanes by >10 kcal/mol. This report describes a catalytic reductive methylenecyclopropanation reaction of simple olefins, utilizing 1,1-dichloroalkenes as vinylidene precursors. The reaction is promoted by a dinuclear Ni catalyst, which is proposed to access Ni(vinylidenoid) intermediates via C-Cl oxidative addition.
亚甲基环丙烷是重要的合成中间体，其应变能超过饱和环丙烷超过 10 kcal/mol。本报告描述了一种利用 1,1-二卤代烯烃作为亚乙烯基前体的简单烯烃的催化还原亚甲基环丙烷化反应。该反应由双核 Ni 催化剂促进，该催化剂通过 C-Cl 氧化加成来生成 Ni(亚乙烯基)中间体。
