Scott D G, Salmon M, Scott D L, Blann A, Bacon P A, Walton K W, Oakland C D, Slaney G F
Clin Rheumatol. 1986 Dec;5(4):517-22.
Takayasu's arteritis is an inflammatory panarteritis of unknown aetiology affecting large elastic arteries. We examined a segment of abnormal common carotid artery removed at by-pass surgery from a 23-year-old man with typical angiographic features of Takayasu's arteritis. Using monoclonal antibodies we were able to demonstrate marked infiltration of the arterial wall with OKT8 positive lymphocytes (suppressor/cytotoxic cells) but not with OKT4 positive lymphocytes (helper cells). Studies of circulating lymphocytes showed increased numbers of "activated" cells and increased in vitro cytotoxicity against cultured human umbilical cord endothelial cells, compared to normal lymphocytes. Cellular immunological mechanisms may play an important role in the pathogenesis of Takayasu's arteritis, possibly through the direct action of cytotoxic T cells on large elastic arteries.
高安动脉炎是一种病因不明的炎症性全动脉炎，累及大的弹性动脉。我们检查了一名23岁患有典型高安动脉炎血管造影特征的男性患者，在旁路手术中切除的一段异常颈总动脉。使用单克隆抗体，我们能够证明动脉壁有明显的OKT8阳性淋巴细胞（抑制/细胞毒性细胞）浸润，但没有OKT4阳性淋巴细胞（辅助细胞）浸润。循环淋巴细胞研究显示，与正常淋巴细胞相比，“活化”细胞数量增加，对培养的人脐静脉内皮细胞的体外细胞毒性增加。细胞免疫机制可能在高安动脉炎的发病机制中起重要作用，可能是通过细胞毒性T细胞对大弹性动脉的直接作用。
