Gulati R, Chopra P, Talwar K K, Kumar R
Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
Indian Heart J. 1998 Jan-Feb;50(1):69-72.
Takayasu's arteritis, also known as 'non-specific aortoarteritis' is an inflammatory disease of the aorta and its major branches. It also involves the pulmonary artery. The aetiology of the disease is not known so far. Abnormalities of the endothelial cells in terms of their structure and function are seen in the pathology of a number of diseases affecting the blood vessel wall. However, involvement of the endothelial cells in non-specific aortoarteritis is not known. In an effort to identify the role of endothelial cells in the pathogenesis of Takayasu's arteritis, peripheral blood lymphocytes isolated from the blood of patients suffering from Takayasu's arteritis were cultured in the presence of endothelial cells alone and in the presence of mitogens concanavalin-A and phytohaemagglutinin-P. The peripheral blood lymphocytes of patients with Takayasu's arteritis showed a significantly decreased blastogenic response to the mitogen concanavalin-A when cultured in the presence of endothelial cells. Our result thus suggests that endothelial cells may probably induce an inhibitory effect on the lymphocytes in patients with Takayasu's arteritis.
高安动脉炎，也被称为“非特异性主动脉动脉炎”，是一种累及主动脉及其主要分支的炎症性疾病。它也会累及肺动脉。该病的病因至今尚不明确。在许多影响血管壁的疾病病理学中，可见内皮细胞在结构和功能方面的异常。然而，内皮细胞是否参与非特异性主动脉动脉炎尚不清楚。为了确定内皮细胞在高安动脉炎发病机制中的作用，从高安动脉炎患者血液中分离出的外周血淋巴细胞，分别在仅存在内皮细胞的情况下，以及在有丝分裂原伴刀豆球蛋白A和植物血凝素-P存在的情况下进行培养。高安动脉炎患者的外周血淋巴细胞在与内皮细胞共同培养时，对有丝分裂原伴刀豆球蛋白A的增殖反应显著降低。因此，我们的结果表明，内皮细胞可能对高安动脉炎患者的淋巴细胞产生抑制作用。
