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在产KPC-2的肺炎克雷伯菌ST340/CG258的医院相关克隆中携带非Tn4401遗传元件（NTE）的IncX3质粒。

IncX3 plasmid harboring a non-Tn4401 genetic element (NTE) in a hospital-associated clone of KPC-2-producing Klebsiella pneumoniae ST340/CG258.

作者信息

Cerdeira Louise T, Cunha Marcos P V, Francisco Gabriela R, Bueno Maria Fernanda C, Araujo Bruna F, Ribas Rosineide M, Gontijo-Filho Paulo P, Knöbl Terezinha, de Oliveira Garcia Doroti, Lincopan Nilton

机构信息

Department of Clinical Analysis, School of Pharmacy, Universidade de São Paulo, São Paulo, Brazil.

School of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.

出版信息

Diagn Microbiol Infect Dis. 2017 Oct;89(2):164-167. doi: 10.1016/j.diagmicrobio.2017.06.022. Epub 2017 Jul 1.

DOI:10.1016/j.diagmicrobio.2017.06.022
PMID:28807400
Abstract

IncX-type plasmids have achieved clinical significance for their contribution in the dissemination of genes confering resistance to carbapenems (most bla- and bla-type genes) and polymyxins (mcr-type genes), both antibiotics considered last resort for multidrug-resistant Gram-negative infections. In this study, we report the identification and complete sequence analysis of an IncX3 plasmid (designated pKP1194a) carrying a non-Tn4401 genetic element (NTE) of tnpR-tnpA (partial)-bla-ΔISKpn6/traN, originating from a hospital-associated lineage of K. pneumoniae belonging to the ST340/CG258, with epidemiological link to Brazil.

摘要

IncX型质粒因其在传播对碳青霉烯类抗生素（大多数bla-和bla-型基因）和多粘菌素（mcr-型基因）耐药的基因方面所起的作用而具有临床意义，这两种抗生素被视为治疗多重耐药革兰氏阴性菌感染的最后手段。在本研究中，我们报告了一个IncX3质粒（命名为pKP1194a）的鉴定和全序列分析，该质粒携带一个tnpR-tnpA（部分）-bla-ΔISKpn6/traN的非Tn4401遗传元件（NTE），其源自一株属于ST340/CG258的医院相关肺炎克雷伯菌菌株，与巴西存在流行病学关联。

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